高等学校化学学报2017，Vol.38Issue(11)：1927-1934,8.DOI:10.7503/cjcu20170176
抗癌载药体系Fe3O4@ZIF-8@PA的合成及药物释放
Preparation and Drug Release of Anti-cancer Fe3O4@ZIF-8@PA System Loaded with Drug
摘要
Abstract
An anti-cancer and loading drug system was prepared. Fe3O4 nanopartiles prepared by hydrother-mal method was chosen as substrate to design and fabricate pH responsive magnetic nanocomposites Fe3O4@ZIF-8@PA with core-shell structure. This nanomaterial exhibited high saturation of 35. 46 A·m2/g and maintained well magnetic property. Fe3O4 nanopartiles showed spherical structure and good dispersion. Compared with the substrate, the particle size of composite microsphere increased significantly, but still con-form to the ideal carrier material size. In addition, the carriers with porous structures showed large surface are-a, high drug loading efficiency and capacity for doxorubicin(DOX) of up to 96. 4% and 144. 6 mg/g. The drug release of nanopartiles loaded with drug was studied in pH=7. 4 and 5. 0. The total released percentage of two kinds of pH were 39. 8% and 78. 6%, respectively. The drug releasing experiment was also to perform to verify the constructed nanocarriers excellent pH-response. The introduction of phytic acid with inhibition to cancer cells made it possible that the carriers could kill tumor cells. The methyl thiazolyl tetrazolium( MTT) test act on human osteosarcoma cell line( MG-63) was also carried out in vitro to demonstrate the combination effect of anticancer between the carriers and DOX.关键词
pH响应性/协同作用/磁性纳米复合材料/核壳结构/植酸/药物释放Key words
pH-responsiveness/Combination therapy/Magnetic nanocomposite/Core-shell structure/Phytic acid/Drug release分类
化学化工引用本文复制引用
王晓丹,徐丹丹,吕维忠,刘婧媛,刘琦,景晓燕,王君..抗癌载药体系Fe3O4@ZIF-8@PA的合成及药物释放[J].高等学校化学学报,2017,38(11):1927-1934,8.基金项目
国家自然科学基金(批准号:51402065)资助.Supported by the National Natural Science Foundation of China( No. 51402065) . （批准号:51402065）
