国际神经病学神经外科学杂志2017，Vol.44Issue(5)：492-497,6.DOI:10.16636/j.cnki.jinn.2017.05.009
中老年初次脑梗死发作后血管性痴呆的相关影响因素分析
Influencing factors for vascular dementia after the first brain infarction attack in middle-aged and elderly patients
摘要
Abstract
Objective To investigate the influencing factors for vascular dementia (VD) after the first brain infarction attack in middle-aged and elderly patients.Methods A total of 213 patients aged 45-75 years who experienced the first brain infarction attack were enrolled,and according to the cognitive function at 3 months after the attack,these patients were divided into VD group and control group.The two groups were compared in terms of general data and examination results.The univariate and multivariate logistic regression analyses were used to screen out the influencing factors for VD,and the receiver operating characteristic (ROC) curve was used to investigate the diagnostic cut-off values of related indices.Results The logistic regression analysis showed that Hcy (OR =5.921,P ＜0.001),age (OR =6.030,P ＜0.001),infarct area (OR =1.372,P ＜0.001),brain atrophy (OR =5.226,P =0.003),leukodystrophy (OR =1.434,P =0.025),hypertension (OR =2.346,P =0.027),diabetes (OR =2.271,P =0.042),education level (OR =0.195,P ＜ 0.001),and rehabilitation exercise after discharge (OR =0.416,P =0.004) were independent influencing factors for VD after cerebral infarction;the cut-off values of Hey,age,and infarct area were 18.08 μmol/L,61.1 years and 5.67 cm2,respectively.Conclusions In middle-aged and elderly patients experiencing the first brain infarction attack,high Hey,old age,large infarct area,and comorbidities of brain atrophy,leukodystrophy,hypertension,and diabetes may increase the risk of VD,while high education level and rehabilitation exercise can reduce the incidence of VD.关键词
中老年/初次脑梗死/血管性痴呆/Logistic回归/危险因素Key words
middle-aged and elderly people/first cerebral infarction attack/vascular dementia/Logistic regression/risk factor引用本文复制引用
张钱林,孟兰芳,赵丽娟,袁丽品,张杰文..中老年初次脑梗死发作后血管性痴呆的相关影响因素分析[J].国际神经病学神经外科学杂志,2017,44(5):492-497,6.基金项目
河南省科技攻关项目(122102310160) （122102310160）
