高校化学工程学报2017，Vol.31Issue(5)：1143-1149,7.DOI:10.3969/j.issn.1003-9015.2017.05.017
Cs/Gel/HA/MWCNTs支架的制备及其生物相容性评价
Fabrication and Biocompatibility of Chitosan/Gelatin/Hyaluronic Acid/MWCNTs Scaffolds
摘要
Abstract
Multi-walled carbon nanotubes (MWCNTs) were chosen to optimize the performance of Cs/Gel/HA composed scaffolds. Cs/Gel/HA/MWCNTs electrical conductive scaffolds with MWCNTs contents of 2%, 6% and 10% were prepared by freeze-drying. The physical and chemical properties together with biocompatibility of the scaffolds were evaluated. The pore size of the scaffolds is 90~130 μm with porosity of 83%~96%. MWCNTs can increase pore wall roughness and enhance scaffold hydrophobicity. The electrical conductivity of the scaffolds increases with the increase of MWCNTs contents, which can reach to 133.82% of that of the control. Cell viability of the scaffold with MWCNTs content of 6% can be increased to 111.07% of that of the control and cell adhesion rate increases too. Preliminary study shows that the Cs/Gel/HA/MWCNTs electrical conductive scaffolds have better biocompatibility and can be further applied in nerve tissue engineering.关键词
多壁碳纳米管/PC12细胞/导电支架/生物相容性Key words
multi-walled carbon nanotubes(MWCNTs)/PC12 cells/electrical conductive scaffolds分类
生物科学引用本文复制引用
朱智博,关水,王树萍,王先犇,刘天庆,马学虎..Cs/Gel/HA/MWCNTs支架的制备及其生物相容性评价[J].高校化学工程学报,2017,31(5):1143-1149,7.基金项目
国家自然科学基金(31670767) （31670767）
中央高校基本科研业务费专项资金资助项目(DUT16QY08, DUT16RC(3)098, DUT16ZD227). （DUT16QY08, DUT16RC(3）
