中医学报2017，Vol.32Issue(10)：1814-1820,7.DOI:10.16368/j.issn.1674-8999.2017.10.478
中医药联合抗病毒治疗对乙型肝炎相关性肝硬变患者肝癌发生情况的影响
Effect of TCM Combined with Antiviral Therapy on Occurrence of Liver Cancer of Patients with Hepatitis B-related Cirrhosis
摘要
Abstract
Objective:To observe the effect of TCM combined with antiviral therapy on occurrence of liver cancer in patients with hepatitis B-related cirrhosis.Methods:The clinical data of 513 patients with hepatitis B-related cirrhosis were analyzed retrospectively.The clinical data were divided into 291 cases of western medicine group and 222 cases of integrative medicine group.Both groups were treated with one kind of medicine of Anluo Huaxian pill,Compound Biejia Ruangan tablet,Fuzheng Huayu capsule and Luoshugan tablet.The incidence of liver cancer in the two groups was compared and the incidence of that in different CU-HCC risk classifications as well as in different clinical stages.The end point for the observation was the diagnosis of liver cancer or the follow-up time being 5 a.Results:The incidence of hepatocellular carcinoma was 26.6％ in the Integrative medicine group,which was significantly lower than that (33.7％) of the western medicine group(P =0.034 ＜ 0.05).The incidence of hepatocellular carcinoma (28.3％) in CU-HCC high risk patients was significantly lower than that (36.6％) of westcrn medicine group (P =0.023 ＜0.05).In patients in compensatory stage,the incidence of hepatocellular carcinoma (18.3％) was significantly lower than that (33.1％) of the western medicine group (P =0.003 ＜ 0.05).Conclusion:Chinese medicine combined with antiviral therapy for hepatitis B-related cirrhosis can effectively reduce the incidence of liver cancer in patients,especially for patients with high risk score of CU-HCC,and can reduce the occurrence of liver cancer in patients in compensatory stage.关键词
乙型肝炎相关性肝硬变/肝癌/抗病毒治疗/中医药治疗/中西医结合Key words
hepatitis B-related cirrhosis/liver cancer/antiviral therapy/TCM therapy/combination of Chinese and Western medicine分类
医药卫生引用本文复制引用
贾云飞,杨晋翔,王宪波,贾玉,陈泽慧,邢恩龙,王瑞瑞..中医药联合抗病毒治疗对乙型肝炎相关性肝硬变患者肝癌发生情况的影响[J].中医学报,2017,32(10):1814-1820,7.基金项目
重大传染病防治协同创新中心(2011协同创新中心)项目(PXM2015-014226-000058) （2011协同创新中心）
北京中医药大学优秀青年骨干教师专项计划(2016-JYB-QNJSZX013) （2016-JYB-QNJSZX013）
