中医学报2017，Vol.32Issue(10)：1870-1874,5.DOI:10.16368/j.issn.1674-8999.2017.10.492
豁痰祛瘀方联合大剂量rt-PA溶栓治疗急性肺栓塞临床研究
Clinical Study on Huotan Quyu Decoction Combined with Large Doses of rt-PA Thrombolysis in the Treatment of Acute Pulmonary Embolism
摘要
Abstract
Objective:To investigate the clinical efficacy of Huotan Quyu decoction combined with large doses of recombinant tissue-type plasminogen activator (rt-PA) thrombolysis in the treatment of acute pulmonary embolism (APE) and its influence on TCM syndrome integral,blood gas analysis index,tumor necrosis factor-alpha(TNF-α） and D-Dimer level.Methods:142 cases of APE patients were divided into control group(n =71) and observation group by draw lots.Control group took large doses of rt-PA thrombolysis and observation group took Huotan Quyu decoction on the basis of control group.The arterial blood gas analysis (PCO2,PO2),clinical symptom,TNF-α,D-Dimer level of two groups before and after treatment were compared,and clinical efficacy of two groups were evaluated.Results:The effective rate of observation group was 94.37％ (67/71),which was significantly higher than 81.69％ (58/71) of control group (P ＜ 0.05);after treatment,TCM syndrome integral of the observation group was (9.36 ± 1.55) points,the control group was (15.64 ± 1.47),the difference was statistically significant (P ＜ 0.05).After treatment,PCO2,PO2 of the control group respectively were (33.52 ± 1.26) mm Hg (1 mm Hg =0.133 kPa),(75.63 ± 1.67) mm Hg,and the observation group were respectively (37.21 ± 1.33) mm Hg,(80.24 ± 1.87) mm Hg,the differences were statistically significant (P ＜ 0.05).After treatment,TNF-α,D-two dimers of the control group were (4.35 ± 1.42) μg · L-1,(486.52 ± 121.42) μg · L-1,and the observation group respectively (2.52 ±0.87) μg · L-1,(425.63 ± 102.35) μg · L-1,and the differences were statistically significant (P ＜ 0.05).Conclusion:Huotan Quyu decoction combined with large doses of rt-PA thrombolysis for treating APE can effectively improve clinical efficacy,relieve clinical symptom and improve blood gas analysis index,reduce the level of TNF-α alpha and D-Dimer two dimer level.关键词
豁痰祛瘀方/重组织型纤溶酶原激活剂/急性肺栓塞/血气分析/肿瘤坏死因子-α/D-二聚体/中西医结合Key words
Huotan Quyu decoction/recombinant tissue-type plasminogen activator/acute pulmonary embolism/blood gas analysis/tumor necrosis factor alpha/D-Dimer/combination of traditional Chinese and Western medicine分类
医药卫生引用本文复制引用
林浩,杨润华..豁痰祛瘀方联合大剂量rt-PA溶栓治疗急性肺栓塞临床研究[J].中医学报,2017,32(10):1870-1874,5.基金项目
江苏省中医药管理局课题(LZ09041) （LZ09041）
江苏省医学重点人才项目(RC2011066) （RC2011066）
