化工进展2017，Vol.36Issue(10)：3826-3831,6.DOI:10.16085/j.issn.1000-6613.2017-0245
大蒜素/海藻酸钠/明胶/壳聚糖复合微球的制备及性能
Preparation and properties of allicin/sodium alginate/gelatin/chitosan composite microspheres
摘要
Abstract
Sodium alginate/gelatin/chitosan composite microspheres were prepared by complex coacervation method using allicin as model drug.The effects of different conditions of swelling,drug loading and sustained release of DSGCM were investigated.The results showed that,when gelatin and sodium alginate (mass ratio 1 ∶ 3) was 2％ and the allicin and the mix gel ratio was 1 ∶ 2,the preparation of DSGCM was spherical with particle sizes in the range of 0.8-0.9mm,and the drug loading and the entrapment efficiency were 24.3％ and 69.4％,respectively.The composite microspheres was sensitive to pH,and the swelling rate of DSGCM was 450％ in pH=7.4 media.The drug release process fitted well with the Higuchi equation kinetic model.The addition of gelatin could delay the drug release of DSGCM.关键词
大蒜素/海藻酸钠/明胶/壳聚糖/复合微球Key words
allicin/sodium alginate/gelatin/chitosan/composite microspheres分类
化学化工引用本文复制引用
辛露露,李付军,薛飞,张保华..大蒜素/海藻酸钠/明胶/壳聚糖复合微球的制备及性能[J].化工进展,2017,36(10):3826-3831,6.基金项目
国家自然基金(31501682)、山东省自然科学基金(ZR2014CM039,ZR2014EL012)及青岛农业大学高层次人才科研基金(631333)项目. （31501682）
