吉林大学学报（理学版）2017，Vol.55Issue(5)：1329-1335,7.DOI:10.13413/j.cnki.jdxblxb.2017.05.51
有机铵盐阳离子对Fe取代Keggin型磷钨酸盐的结构、形貌及体外抗肿瘤活性的影响
Effects of Organic Ammonium Cations on Structure, Morphology and in vitro Anti-tumor Activity of Fe (Ⅲ)-Substituted Keggin-Type Phosphotungstates
摘要
Abstract
Three mono-Fe (Ⅲ)-substituted Keggin-type phosphotungstates with different organic ammonium cations were systhesized:[CTA]4PWu Fe(H2O) O39 (CTAFe),[TEA]4PWu Fe(H2O) O39 (TEAFe) and [TMA]4 PWn Fe (H2 O) O39 (TMAFe) (CTA =cetyl trimethyl ammonium bromide,TEA=tetraethyl ammonium bromide,TMA=tetramethyl ammonium bromide).The structure and morphology of three phosphotungstates were characterized by infrared spectroscopy (IR),UV-visible spectroscopy (UV-Vis),X-ray diffraction (XRD) and scanning electron microscopy (SEM).The inhibitory effect of three phosphotungstates on the growth of human colorectal carcinoma HCT116,HT29 cells and rat colorectal carcinoma CT26 cells was studied by MTT assay.The results show that the phosphotungstates withdifferent organic ammonium cations still keep Keggin-type structure.But the cations affect the morphology.Longer carbon chain of organic ammonium cations makes crystallinity decrease,no clear crystal morphology of CTAFe.TEAFe and TMAFe have no inhibition on HCT116,HT29 and CT26 cell proliferation,but CTAFe can inhibit these three tumor cells proliferation,showing dose-dependent.The IC50 value for CT26 and HCT116 cell was 0.038,0.08 mg/mL,respectively.So longer carbon chain of organic ammonium cation makes Keggintype phosphotungstates inhibit tumor cell growth stronger.关键词
Keggin型/磷钨酸盐/抗肿瘤/有机铵盐Key words
Keggin-type/phosphotungstate/anti-tumor/organic ammonium分类
化学化工引用本文复制引用
薛莹雪,隋春红,王程,李文亮,白羽..有机铵盐阳离子对Fe取代Keggin型磷钨酸盐的结构、形貌及体外抗肿瘤活性的影响[J].吉林大学学报（理学版）,2017,55(5):1329-1335,7.基金项目
吉林省教育厅科学技术研究项目(批准号:2015398)、吉林省卫生计生青年科技骨干培养项目(批准号:2016Q055)和吉林市科技计划项目(批准号:201464049). （批准号:2015398）
