实用临床医药杂志2017，Vol.21Issue(19)：1-5,5.DOI:10.7619/jcmp.201719001
CKD5D患者骨折风险的相关因素分析
Clinical analysis of risk factors of fracture patients in CKD5D stage
摘要
Abstract
Objective To investigate the risk factors of fracture patients in CKD5D stage.Methods A total of 124 CKD5D patients according to suffering fracture or not in past or at present were divided into fracture group and non-fracture group.Clinical data of age,sex,height,body mass index(BMI),dialysis duration,dialysis patterns,body mass index(BMI),hypertension,diabetes mellitus (DM) history,drug taking history were recorded.Laboratory examinations included hemoglobin (Hb),hematocrit (Hct),serum creatinine (Scr),blood urea nitrogen (Bun),albumin (A),triglyceride (TG),cholesterol(TC),high-density lipoprotein (HDL),low density lipoprotein (LDL),serum sodium (Na +),serum calcium (Ca2 +),serum phosphorus (P),parathyroid hormone (PTH),alkaline phosphatase (AKP),and 25 (OH) VitD.And bone mass density (BMD) were measured.Results The fracture patients had longer dialysis duration,higher of hemodialysis ratio,higher serum Ca2 +,serum P,serum PTH and AKP,lower T and Z values of bone density than those patients without fracture.Univariate regression analysis of fracture risk suggested that dialysis age,high calcium,high phosphorus,high PTH,high AKP,high 25 (OH) VitD and fracture were positively correlated with peritoneal dialysis,and was negatively correlated with the use of calcium and peritoneal dialysis.The Multivariate regression analysis showed that high PTH,high AKP was positively correlated with fracture occurrence,lumbar vertebra bone density and the use of calcium were negatively correlated with fracture.Conclusion Low bone mineral density is an important risk factor for fracture.The use of calcium can reduce the risk of fracture.High PTH and high AKP should be actively intervened in CKD5D patients.关键词
慢性肾脏病/维持性透析/骨折/骨密度Key words
chronic kidney disease/maintenance dialysis/fracture/bone density分类
医药卫生引用本文复制引用
刘伟英,许雪强,邬步云,毛慧娟,邢昌赢..CKD5D患者骨折风险的相关因素分析[J].实用临床医药杂志,2017,21(19):1-5,5.基金项目
江苏省教育厅六大人才高峰(WSN-056) （WSN-056）
“十二五”国家科技支撑计划项目(2011BAll0808) （2011BAll0808）
中国医院协会血液净化质量控制研究(CHABP2016-17) （CHABP2016-17）
江苏省青年自然科学基金(BK20151022) （BK20151022）
