实用临床医药杂志2017，Vol.21Issue(19)：63-65,3.DOI:10.7619/jcmp.201719018
子宫内膜异位症患者腹腔镜术后应用促性腺激素释放激素类似物的效果观察
Effect of gonadotropin releasing hormone analogues after laparoscopic surgery on treatment of patients with endometriosis
摘要
Abstract
Objective To investigate the effect of gonadotropin-releasing hormone antagonist (GnRHa) and gestrinone after laparoscopic surgery in patients with endometriosis.Methods Ninety patients with endometriosis who underwent laparoscopic surgery in our hospital were selected as the subjects.The patients in the control group were treated with gestrinone,while the observation group received GnRHa treatment.Treatment efficacy after treatment,reproductive hormone levels,adverse reactions and recurrence condition were compared.Results The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant (93.3％ vs.71.1％,P ＜ 0.05).The levels of serum reproductive hormone (FSH,LH,E2,PRL) in the two groups were significantly lower than treatment before (P ＜ 0.05),and the levels of FSH,LH in the observation group were significantly lower than the control group (P ＜ 0.05).The incidence of adverse reactions showed no significant difference (P ＞ 0.05).The patients in the two groups were followed up for 1 to 2 years.Among them,9 cases had recurrence in the control group and 3 cases in the observation group,and significant difference was seen between the two groups (P ＜0.05).Conclusion GnRHa therapy is more safe,and effective and has lower relapse rate.关键词
子宫内膜异位症/腹腔镜/促性腺激素释放激素拮抗剂/疗效Key words
endometriosis/laparoscopy/gonadotropin releasing hormone antagonists/efficacy分类
医药卫生引用本文复制引用
张凤,赵绍杰,王金梅..子宫内膜异位症患者腹腔镜术后应用促性腺激素释放激素类似物的效果观察[J].实用临床医药杂志,2017,21(19):63-65,3.基金项目
江苏省自然科学基金资助项目(BK2003104) （BK2003104）
