兰州大学学报（医学版）2017，Vol.43Issue(5)：13-17,5.DOI:10.13885/j.issn.1000-2812.2017.05.003
血清MCP-1水平及其基因多态性与2型糖尿病周围神经病变的相关性
Association of the serum MCP-1 concentration and genetic polymorphism with diabetic peripheral neuropathy in type 2 diabetes mellitus
摘要
Abstract
Objective To investigate into the association of MCP-1 serum level with MCP-1-2518A/G polymorphism and diabetic peripheral neuropathy in the Han population in Gansu Province,China.Methods The serum monocyte chemoattractant protein-1 (MCP-1) concentration and MCP-1-2518A/G polymorphism were measured in normal control,and non-diabetic peripheral neuropathy and diabetic peripheral neuropathy patients by ELISA and TaqMan SNP Genotyping Assays,plasma biological and chemical quota were measured at the same time.Results The serum MCP-1 concentration was significantly increased in NDPN and DPN patients (P ＜ 0.05).There was no correlation between the MCP-1-2518A/G polymorphism with the serum MCP-1 level and diabetic peripheral neuropathy.Multiple regression analysis showed that serum levels of MCP-1 were positively correlated with DPN,TG;logistic regression analysis showed that MCP-1 levels,age,FPG as risk factors for DPN.Conclusion MCP-1 has been involved in the development of type 2 diabetes and diabetic peripheral neuropathy in the northwest Han Chinese population.The serum MCP-1 level was positively correlated with diabetic peripheral neuropathy,triglyceride.MCP-1 as a risk factor for DPN might cause the prevalence rate of DPN to increase.关键词
单核细胞趋化蛋白-1/糖尿病周围神经病变/基因多态性Key words
monocyte chemcattractant protein-1/diabetic peripheral neuropathy/genetic polymorphism分类
医药卫生引用本文复制引用
马芙蓉,吉尚戎,陈慧,何丽蓉,任旋,岳瑞宏..血清MCP-1水平及其基因多态性与2型糖尿病周围神经病变的相关性[J].兰州大学学报（医学版）,2017,43(5):13-17,5.基金项目
中央高校基本科研业务费专项资金项目(lzujbky-2010-172) （lzujbky-2010-172）
