青岛大学医学院学报2017，Vol.53Issue(4)：420-423,4.DOI:10.13361/j.qdyxy.201704014
基因COMT472G ＞A和NQO1609C＞T多态性与山东汉族子痫前期遗传易感性的关系
ASSOCIATION OF COMT 472G ＞A AND NQO1 609C＞ T POLYMORPHISMS WITH GENETIC SUSCEPTIBILITY OF PRE-ECLAMPSIA IN HAN CHINESE POPULATION IN SHANDONG, CHINA
刘静静 1高凯旋 1井忠翠 1赵慧芳 2刘世国 3王海燕1
作者信息
- 1. 青岛大学附属医院输血科,山东青岛266003
- 2. 青岛大学附属医院妇产科,山东青岛266003
- 3. 青岛大学附属医院产前诊断中心,山东青岛266003
- 折叠
摘要
Abstract
Objective To investigate the association of COMT 472G＞A (rs4680) and NQO1 609C＞T (rs1800566) polymorphisms with genetic susceptibility of preeclampsia (PE) in Han Chinese population in Shandong,China.Methods Quantitative real-time PCR was used to analyze and compare the genotypes of COMT 472G＞A and NQO1 609C＞T between 800 normal pregnant women (control group) and 600 pregnant women with PE (PE group),all selected from the Han Chinese population in Shandong Results There were no significant differences between the two groups in genotype and allele distributions of COMT 472G＞A and NQO1 609C＞T (P＞0.05).Conclusion COMT 472G＞A and NQO1 609C＞T polymorphisms are not associated with the development of PE in Han women in Shandong.关键词
先兆子痫/基因,COMT/基因,NQO1/多态性,单核苷酸Key words
pre-eclampsia/genes, COMT/genes, NQO1/polymorphisms, single nucleotide分类
医药卫生引用本文复制引用
刘静静,高凯旋,井忠翠,赵慧芳,刘世国,王海燕..基因COMT472G ＞A和NQO1609C＞T多态性与山东汉族子痫前期遗传易感性的关系[J].青岛大学医学院学报,2017,53(4):420-423,4.
