器官移植2017，Vol.8Issue(6)：430-434,5.DOI:10.3969/j.issn.1674-7445.2017.06.004
公民逝世后器官捐献供肝保护及功能评估临床分析
Clinical analysis on donor liver protection and function evaluation for organ donation after citizen's death
摘要
Abstract
Objective To summarize the preliminary experience of donor liver protection and function evaluation for organ donation after citizen's death. Methods Clinical data of 35 donors from organ donation after citizen's death and 33 recipients were retrospectively analyzed. Donor liver procurement and clinical prognosis of the recipients were summarized. According to serum level of sodium ion (serum sodium) before organ procurement, all recipients were divided into the serum sodium <155 mmol/L, 155-160 mmol/L and 161-180 mmol/L groups. The incidence of liver graft dysfunction early after liver transplantation was statistically compared among three groups. Results In 35 donors,27 cases were Chinese type Ⅱ and 8 cases were Chinese type Ⅲ. Thirty-three donor livers were used for liver transplantation, and the remaining 2 cases of donor livers were excluded due to congestive cirrhosis. In 33 liver transplantation recipients, 30 cases were successfully recovered. The liver function was gradually restored at postoperative 7-14 d, and normal liver function was obtained during long-term follow-up. Postoperatively, 3 recipients died including 2 cases dying from portal vein thrombosis and 1 case from pulmonary infection complicated with multiple organ failure. The incidence of early liver graft dysfunction of the recipients after liver transplantation was 18%, 23% and 4/5 in the serum sodium <155 mmol/L, 155-160 mmol/L and 161-180 mmol/L groups, respectively. Statistical significance was observed between the 161-180 mmol/L and <155 mmol/L groups (P<0.05). Conclusions Timely protection of donor liver, accurate evaluation and maintenance of liver function play a pivotal role in enhancing the utilization rate of donor liver, maintaining liver function and yielding good efficacy for transplantation.关键词
公民逝世后器官捐献/供肝保护/功能评估/肝移植/高钠血症/移植肝功能不全/并发症/门静脉血栓Key words
Organ donation after citizen's death/Donor liver protection/Function evaluation/Liver transplantation/Hypernatremia/Liver graft dysfunction/Complication/Portal vein thrombosis分类
医药卫生引用本文复制引用
丁利民,徐志丹,李新长,罗文峰,龙成美,罗来邦..公民逝世后器官捐献供肝保护及功能评估临床分析[J].器官移植,2017,8(6):430-434,5.基金项目
江西省卫计委科技计划(20155012) （20155012）
