器官移植2017，Vol.8Issue(6)：435-439,5.DOI:10.3969/j.issn.1674-7445.2017.06.005
公民逝世后器官捐献供肝肝移植单中心经验总结
Liver transplantation from donor liver of organ donation after citizen's death: a single center experience
摘要
Abstract
Objective To evaluate the application value of donor liver from organ donation after citizen's death (organ donation) in clinical liver transplantation. Methods Clinical data of 75 pairs of donors and recipients undergoing liver transplantation from organ donation in the First People's Hospital of Foshan from October 2011 to December 2016 were retrospectively analyzed. The conditions of the donors were strictly evaluated. Clinical prognosis and the incidence of postoperative complications of the recipients were summarized. Results The 1-year and 3-year accumulated survival rates of 75 liver transplantation recipients were 88% and 78%. Four recipients died from the recurrence and metastasis of liver cancer, 1 case from graft-versus-host disease, 1 case from severe pulmonary infection, 1 case from recurrence of virus B hepatitis (hepatitis B) and liver failure, 1 case from postoperative multiple organ failure and 1 case from massive hemorrhage of the upper digestive tract. Thirteen recipients suffered from biliary tract stenosis. One case was mitigated spontaneously and 1 recipient was healed after percutaneous transhepatic biliary drainage (PTBD). Eleven cases were treated with endoscopic retrograde cholangiopancreatography (ERCP). Among them, 5 cases were healed,2 recipients were switched to choledochojejunostomy and 4 cases were still monitored in clinical practice. Conclusions Liver transplantation from organ donation yields high clinical efficacy. Strict evaluation of donor conditions, standard perioperative management of the recipients, maintenance immunosuppressive therapy without adrenocortical hormone,timely and effective treatment of complications, regular postoperative follow-up are pivotal measures to guarantee the success of liver transplantation from organ donation and long-term survival of the recipients.关键词
器官捐献/公民逝世后器官捐献/肝移植/并发症/感染/器官获取组织/肝细胞癌/乙型病毒性肝炎/肝衰竭Key words
Organ donation/Organ donation after citizen's death/Liver transplantation/Complication/Infection/Organ Procurement Organization/Hepatocellular carcinoma/Virus B hepatitis/Liver failure分类
医药卫生引用本文复制引用
邓斐文,陈焕伟,甄作均..公民逝世后器官捐献供肝肝移植单中心经验总结[J].器官移植,2017,8(6):435-439,5.基金项目
广东省医学科研基金(A2014697) （A2014697）
佛山市医学类科技攻关项目(2014AB00263) （2014AB00263）
佛山市卫生局医学科研基金(2014029) （2014029）
