器官移植2017，Vol.8Issue(6)：455-459,5.DOI:10.3969/j.issn.1674-7445.2017.06.009
双重膜滤过式血浆置换清除肾移植受者供体特异性抗体的临床观察
Clinical observation on the removal of donor specific antibody by double filtration plasmapheresis in renal transplant recipients
摘要
Abstract
Objective To investigate the effect of double filtration plasmapheresis (DFPP) upon the removal of donor specific antibody (DSA) in highly sensitized recipients with renal transplantation. Methods Four highly sensitized recipients undergoing renal transplantation received 7 cycles of DFPP. Luminex technology was adopted to monitor the changes of DSA. Clinical efficacy, incidence of acute rejection and adverse reactions were observed. Results After DFPP, the DSA MFI [1036 (0-4113)] was significantly declined than that before treatment [6446 (2999-12905), Z= -2.503, P=0.012]. No hyperacute rejections occurred in four highly sensitized recipients undergoing renal transplantation.Acute rejection was noted in one case, which was mitigated by postoperative DFPP and adjustment of immunosuppressive agents. During postoperative follow-up, the function of transplant kidney was normal and no rejection reactions occurred. The level of albumin was decreased after DFPP. Conclusions DFPP can effectively remove the DSA in the recipients.It is an efficacious and safe approach to prevent the incidence of acute rejections in highly sensitized recipients after renal transplantation.关键词
双重膜滤过式血浆置换/肾移植/供体特异性抗体(DSA)/受者,高致敏/抗体介导的排斥反应(AMR)/Luminex技术/人类白细胞抗原(HLA)抗体/白蛋白Key words
Double filtration plasmapheresis/Renal transplantation/Donor specific antibody (DSA)/Recipient,highly sensitized/Antibody-mediated rejection/Luminex technology/Human leukocyte antigen (HLA) antibody/Albumin分类
医药卫生引用本文复制引用
廖琪,蒋秋艳,熊艳,王凤英,晏强,邹贵勉,眭维国..双重膜滤过式血浆置换清除肾移植受者供体特异性抗体的临床观察[J].器官移植,2017,8(6):455-459,5.基金项目
广西卫生厅计划课题(Z2013789) （Z2013789）
