生殖医学杂志2017，Vol.26Issue(11)：1100-1103,4.DOI:10.3969/j.issn.1004-3845.2017.11.010
改良长方案联合国产HMG的控制性促排卵方案的临床结局与经济性评价
Clinical outcomes and economic evaluation of a modified long down-regulation combined with domestic HMG in controlled ovarian hyperstimulation of IVF-ET
任建枝 1韩冬梅 1马彩辉 1耿洁 1李萍 1沙爱国1
作者信息
- 1. 解放军第一七四医院生殖医学中心,厦门 361002
- 折叠
摘要
Abstract
Objective:To investigate the effectiveness and economical efficiency of controlled ovarian hyperstimulation (COH) by using a modified long down-regulation protocol combined with domestic HMG in IVF-ET.Methods:The data of 9 063 IVF-ET fresh embryo transfer cycles with modified long regimens were retrospectively analyzed.What kind of Gn would be used is according to the serum LH level on gonadotropin(Gn) starting day,the follicle growth velocity and the changes of LH levels during ovulation induction process.The patients were divided into two groups according to the type of Gn used:the patients used only recombinant FSH(rFSH) in rFSH group;the patients administrated HMG or the combination of HMG and rFSH in HMG group.The effectiveness of two kinds of ovulation induction regimens and clinical outcome were compared between the two groups.Results:Compared the two groups,the patients in rFSH group were younger and had shorter infertile duration(P＜0.05).The duration and dosage of Gn used were more(P＜0.05),but the cost of Gn was significantly less[(2 935.28±1 711.64) vs.(8 413.78±2 049.22) RMB]in HMG group(P＜0.001).The number of oocytes retrieved and embryos was significantly higher,however,the incidence of moderate and severe OHSS was significantly increased in rFSH group(P＜0.01).There were no significant differences in endometrial thickness on HCG day,fertilization rate,high quality embryos,clinical pregnancy rate,implantation rate and early abortion rate between two groups(P＞0.05).Conclusions:After GnRH-a down-regulation,Usage of domestic HMG for ovarian hyperstimulation can get better clinical outcome and reduce the cost of Gn when LH≤1 U/L.关键词
体外受精-胚胎移植/促性腺激素释放激素激动剂/人绝经期促性腺激素/临床结局/经济性Key words
IVF-ET/GnRH agonist/HMG/Clinical outcome/Economical efficiency引用本文复制引用
任建枝,韩冬梅,马彩辉,耿洁,李萍,沙爱国..改良长方案联合国产HMG的控制性促排卵方案的临床结局与经济性评价[J].生殖医学杂志,2017,26(11):1100-1103,4.
