西北国防医学杂志2017，Vol.38Issue(10)：631-634,4.DOI:10.16021/j.cnki.1007-8622.2017.10.001
高原与亚高原环境下大鼠力竭运动后氧化损伤与炎症反应研究
Research of the oxidative damage and inflammatory reaction in rats after exhaustive exercise in plateau and sub-plateau environment
摘要
Abstract
Objective:To investigate the changes of oxidative damage and inflammatory reaction at different time in rats after subjected exhaustive exercise in plateau and sub-plateau environment.Methods:A total of 72 rats were randomly divided into high altitude group (n =36) and sub-high altitude group (n =36).Then each group of high altitude and sub-high altitude were randomly divided into six groups (n =6) according to sampling time.The rats were carried out weight-bearing swimming test till exhaustion.The swimming time was recorded,and MDA,T-SOD and TNF-α were determined.Results:The swimming time of high altitude group was significantly shorter than that of sub-high altitude group.The content of serum MDA and TNF-α had no obvious changes in sub-high altitude group.Compared with the control group at sub-high altitude,the content of serum T-SOD were significantly deceased at 12 h (P＜0.01) and then increased to control level at 24 h.In the high altitude,the content of serum MDA significantly increased at 6 h(P＜0.01) and was still on the rise at 12 h and 24 h,as time continues to 48 h,there was a decline but still higher than the control group (P＜0.05).The content of T-SOD was significantly deceased at 6 h (P＜0.01),when the time continues to 12 h and 24 h,it was increased but still lower than the control group(P＜0.05),then returned to control level at 48 h.The content of TNF-α was significantly inceased at 24 h (P＜0.01) and remained high at 48 h (P ＜ 0.01).Conclusion:Compared with the sub-high altitude group,rats in the high altitude group have a reduction of physical ability.There were much more oxidative damage and inflammatory reaction after exhaustive exercise.关键词
高原/力竭运动/氧化损伤/炎症反应Key words
high altitude/exhaustive exercise/oxidative damage/inflammatory reaction分类
医药卫生引用本文复制引用
张富婷,惠玲..高原与亚高原环境下大鼠力竭运动后氧化损伤与炎症反应研究[J].西北国防医学杂志,2017,38(10):631-634,4.基金项目
全军医药卫生科研基金面上项目(CLZ12JA08) （CLZ12JA08）
