西北国防医学杂志2017，Vol.38Issue(10)：659-662,4.DOI:10.16021/j.cnki.1007-8622.2017.10.008
血清A-FABP和趋化因子CXCL12水平与老年人AIS的发生及严重程度的相关性
Correlation of serum A-FABP and chemokine CXCL12 with occurrence and severity of AIS in the elderly
李凯 1张素平1
作者信息
- 1. 暨南大学附属广州市红十字会医院神经内科,广东广州 510200
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摘要
Abstract
Objective:To study the changes of serum adipocyte fatty acid binding protein (A-FABP) and chemokine CXCL12 levels in the elderly with acute ischemic stroke (AIS),and to explore the correlation between the two indexes and the occurrence and severity of AIS.Methods:Ninety-two elderly patients with AIS in our hospital were selected as AIS group,eighty-three healthy persons for physical examination at the same period in our hospital were selected as control group.Neurological deficits were assessed by using the national institutes of health stroke scale (NIHSS),glasgow coma scale(GCS) was used to judge their consciousness.Enzyme linked immunosorbent assay (ELISA) was used to measure serum levels of A-FABP and CXCL12.AIS patients were followed up for 3 months,and the prognosis was evaluated by mRS.Results:The levels of serum A-FABP and chemokine CXCL12 in AIS group were significantly higher than those in control group (P＜0.05).There were significant differences in the serum levels of A-FABP and chemokine CXCL12 in patients with different infarct size,NIHSS and GCS (P＜0.05).The serum levels of A-FABP and chemokine CXCL12 in patients with poor prognosis were significantly higher than those with good prognosis,the differences were statistically significant (P ＜ 0.05).Conclusion:The levels of serum A-FABP and chemokine CXCL12 in elderly patients with AIS are correlated with the occurrence and severity of AIS.It mayr be an important clinical index for early diagnosis,condition monitoring and prognosis evaluation of AIS in elderly patients.关键词
急性缺血性脑卒中/脂肪型脂肪酸结合蛋白/CXCL12Key words
acute ischemic stroke/adipocyte fatty acid binding protein/CXCL12分类
医药卫生引用本文复制引用
李凯,张素平..血清A-FABP和趋化因子CXCL12水平与老年人AIS的发生及严重程度的相关性[J].西北国防医学杂志,2017,38(10):659-662,4.
