血管内皮生长因子靶向抗体对大鼠角膜碱烧伤后新生血管抑制作用的研究OA北大核心CSTPCD
Inhibitory effects of anti-vascular endothelial growth factor (VEGF) antibody MIL60 on alkali-induced corneal angiogenesis in rats
目的 通过对角膜碱烧伤大鼠模型结膜下注射VEGF靶向抗体MIL60,观察其对角膜新生血管(corneal neovascularization,CoNV)生长的影响,初步探讨MIL60抑制大鼠CoNV生长的基本作用机制.方法 建立碱烧伤诱导的SD大鼠CoNV模型(右眼造模),根据碱烧伤后第1天结膜下注射的药物不同将72只大鼠随机分为:25 mg·mL-1 MIL60组、地塞米松组、MIL60溶剂组和NaCl组.观察并记录CoNV生长情况及角膜的形…查看全部>>
Objective To investigate the efficacy of an anti-vascular endothelial growth factor (VEGF) antibody,MIL60,in inhibiting corneal neovascularization (CoNV) formation in a rat model of alkali cauterization and its involved mechanisms.Methods Rat CoNV model induced by alkali burn was founded in the right eyes,and then 72 cases were randomly divided into four groups according to the subconjunctival administration of medicine next day after the successful establis…查看全部>>
王群;姜严明;赵杰;侯宝杰;吕明;黄一飞
100039 北京市,武警总医院眼科100088 北京市,火箭军总医院眼科100039 北京市,武警总医院眼科100039 北京市,武警总医院眼科100086 北京市,军事医学科学院100053 北京市,解放军总医院眼科
医药卫生
血管内皮生长因子MIL60角膜新生血管碱烧伤
vascular endothelial growth factorMIL60corneal neovascularizationalkali cauterization
《眼科新进展》 2017 (11)
1010-1014,5
武警总医院院内课题(编号:wz2015011)Intrahospital Project of General Hospital of CAPF (No:wz2015011)
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