眼科新进展2017，Vol.37Issue(11)：1083-1087,5.DOI:10.13389/j.cnki.rao.2017.0274
圆锥角膜遗传病因学的研究进展
Research progress on genetic etiology of keratoconus
摘要
Abstract
Keratoconus (KC) is a common cornea ectatic disorder characterized by myopia,irregular astigmatism and other visual impairment caused by corneal thinning and cone-shaped protrusion.With a wide range of effects,the etiology of this disease is unknown,and genetic factors may be involved in its pathogenesis.This paper summarizes the research progress on KC genetic etiology for reviewing the selected candidate genes and loci based on traditional/genome-wide linkage studies,genome-wide association studies and central corneal thickness in recent years.Genetic studies on KC pathogenesis will advance our understanding of this disease and further promote the development of potential therapies.关键词
圆锥角膜/遗传因素/基因Key words
keratoconus/etiology/genetic factors分类
医药卫生引用本文复制引用
容烁,王超英,韩宝雁,李晓娜,陈维毅..圆锥角膜遗传病因学的研究进展[J].眼科新进展,2017,37(11):1083-1087,5.基金项目
国家自然科学基金资助(编号:31271005、11402162)National Natural Science Foundation of China (No:31271005,11402162) （编号:31271005、11402162）
