中国动脉硬化杂志2017，Vol.25Issue(10)：1015-1020,6.
载脂蛋白C3基因rs5128多态性与不同体质指数冠心病患者血脂水平及冠状动脉狭窄程度的相关性
Relationship between the ApoC3 rs5128 polymorphism and plasma lipid levels and the severity of coronary stenosis in coronary heart disease patients with different body mass index
摘要
Abstract
Aim The aim of the study was to investigate the relationship between the ApoC3 rs5128 polymorphism and plasma lipid levels and the severity of coronary stenosis in the coronary heart disease (CHD) patients with different body mass index (BMI) in Chinese Han population.Methods Three hundred and twelve CHD patients were divided into healthy weight group (205 patients) and overweight/obese group (107 patients).Physiological,biochemical and coronary angiographical data were collected for all patients.The severity of coronary stenosis was assessed by the Gensini scoring system.Genome DNA was extracted from peripheral blood leucocytes and the genotypes of the ApoC3 rs5128 polymorphism were determined by polymerase chain reaction-restriction fragment length polymorphism method.Results The overweight/obese patients had higher weight,BMI,prevalence of hypertension,triglyceride (TG),lipoprotein (a),TG/high-density lipoprotein cholesterol (HDLC),total cholesterol (TC)/HDLC,low-density lipoprotein cholesterol (LDLC)/HDLC and apolipoprotein B100 (ApoB100)/apolipoprotein AI (ApoA Ⅰ),and lower HDLC and ApoA Ⅰ than the patients with healthy weight (P＜0.05).In healthy weight group,the G carriers had higher prevalence of hypertension than the patients with the CC genotype (P＜0.05).In overweight/obese group,the G carriers had higher levels of TG and TG/HDLC than the patients with the CC genotype (P＜ 0.05).In healthy weight group and overweight/obese group,there were no significant differences in the distributions of the genotypes or alleles of the rs5128 polymorphism among the tertiles of the Gensini scores.Conclusion The ApoC3 rs5128 polymorphism is significantly associated with plasma TG and TG/HDLC levels,but not with the severity of CHD.关键词
载脂蛋白C3/多态性/冠心病/冠状动脉狭窄/rs5128Key words
Apolipoprotein C3/Polymorphism/Coronary heart disease/Coronary stenosis/rs5128分类
医药卫生引用本文复制引用
张井潇,吕湛,王艳玫,杨阳,欧阳肖肖,宋永砚..载脂蛋白C3基因rs5128多态性与不同体质指数冠心病患者血脂水平及冠状动脉狭窄程度的相关性[J].中国动脉硬化杂志,2017,25(10):1015-1020,6.基金项目
四川省教育厅重点项目(17ZA0172) （17ZA0172）
川北医学院科研创新团队项目(CBY13-TD02) （CBY13-TD02）
