中国兽医科学2017，Vol.47Issue(10)：1326-1330,5.DOI:10.16656/j.issn.1673-4696.2017.10.020
马波沙星在猪多杀性巴氏杆菌感染组织液中药代动力学的研究
Pharmacokinetics of marbofloxacin in tissue cage fluid of pigs infected with Pasteurella multocida
摘要
Abstract
To study the pharmacokinetics of marbofloxacin in the tissue cage fluid of pigs infected with Pasteurella multocida,a tissue cage infection model was included in this study.Two dosages(1.0mg/kg and 2.5 mg/kg) of marbofloxacin were administrated intramuscularly after 0.5 mL of P.multocida saline suspension was injected into tissue-cages for 24 h,and tissue cage fluid samples were sampled as designed scheme.Marbofloxacin concerntration in tissue cage fluid samples was determined by the HPLC.Concentration-time data were analysised with the non-compartment model offered by WinNonlin software.In result,the main pharmacokinetic parameters acquired from different dosages were described as below,1 mg/kg:tmax=4 h± 1.41 h,Cmax=0.30 μg/mL±0.06 μg/mL,AUC=9.96 μg/mL·h± 1.54 μg/mL·h,t1/2β=22.92h±6.83 h;2.5 mg/kg:tmax=5 h± 1.41 h,Cmax=0.71μg/mL±0.09 μg/mL,AUC=21.06 μg/mL·h±3.69 μg/mL·h,t1/2β=20.91 h ±8.57 h.In conclusion,marbofloxacin is absorbed and eliminated slowly in tissue cage fluid ofpigsinfected with P.multocida,and can reach high peak concentration.关键词
马波沙星/药代动力学/多杀性巴氏杆菌/组织液Key words
marbofloxacin/pharmacokinetics/Pasteurella multocida/tissue cage fluid分类
农业科技引用本文复制引用
曾庆林,苏佳,万鹏,裴鹏飞,韩东东,曾振灵..马波沙星在猪多杀性巴氏杆菌感染组织液中药代动力学的研究[J].中国兽医科学,2017,47(10):1326-1330,5.基金项目
国家自然科学基金面上项目(31372480) （31372480）
