中国实用内科杂志2017，Vol.37Issue(10)：871-874,4.DOI:10.19538/j.nk2017100103
肾上腺皮质肿瘤的分子生物学机制
Molecular pathways in human adrenocortical tumors
谷伟军 1母义明1
作者信息
- 1. 中国人民解放军总医院内分泌科,北京100853
- 折叠
摘要
Abstract
T-he recently available genomic sequencing techniques have led to breakthroughs in understanding of the underlying genetic mechanisms in adrenocortical tumors.New major drivers in all tumor types,including KCNJ5,ATP1A1,ATP2B3 and CACNA1D mutations in aldosterone-producing adenomas (APA),PRKACA mutations in cortisol-producing adenomas (CPA),ARMC5 mutations in primary bilateral macronodular adrenocortical hyperplasia (PBMAH) and ZNRF3 mutations in adrenocortical carcinomas (ACC).Identifying the main molecular groups of adrenocortical tumors by extensively gathering the molecular variations is a significant step forward towards precision diagnosis and medicine.关键词
肾上腺皮质瘤/基因Key words
adrenocortical tumors/gene分类
医药卫生引用本文复制引用
谷伟军,母义明..肾上腺皮质肿瘤的分子生物学机制[J].中国实用内科杂志,2017,37(10):871-874,4.
