中国药房2017，Vol.28Issue(31)：4350-4354,5.DOI:10.6039/j.issn.1001-0408.2017.31.08
熟地黄、山茱萸、茯苓单煎液与合煎液中毛蕊花糖苷、没食子酸煎出量的变化
Decoction Amount Changes of Verbascoside and Gallic Acid in Single Decoction and Combined Decoction of Rehmanniae Radix Preparata,Corni Fructus and Poria
摘要
Abstract
OBJECTIVE:To investigate the decoction amount changes of verbascoside,gallic acid in single decoction and com-bined decoction of rehmanniae radix preparata,corni fructus and poria,and provide scientific basis for further study of effective substance basis. METHODS:The single decoction,combined decoction with each 2 medicine and combined decoction with the 3 medicines of rehmanniae radix preparata,corni fructus and poria,were respectively prepared. HPLC was adopted to detect and com-pare the decoction amount of active component verbascoside in rehmanniae radix preparata and active component gallic acid in cor-ni fructus in each group. RESULTS:Compared with single decoction of rehmanniae radix preparata,the decoction amount of ver-bascoside was decreased in combined decoction of poria+rehmanniae radix preparata(P<0.01),decoction amount of verbascoside was increased in combined decoction of corni fructus+rehmanniae radix preparata or combined decoction with the 3 medicines(P<0.01). Compared with single decoction of corni fructus,the decoction amount of gallic acid in each combined decoction was de-creased (P<0.01). CONCLUSIONS:The combined decoction of rehmanniae radix preparata,corni fructus and poria has certain promotion and inhibition effects on the decoction of verbascoside in rehmanniae radix preparata and inhibition effect on the decoc-tion of gallic acid in corni fructus. It is speculated verbascoside may be one of the main components in combined decoction playing the role of effectiveness.关键词
熟地黄/茯苓/山茱萸/合煎/单煎/毛蕊花糖苷/没食子酸/煎出量Key words
Rehmanniae radix preparata/Poria/Corni fructus/Combined decoction/Single decoction/Verbascoside/Gallic acid/Decoction amount分类
医药卫生引用本文复制引用
杨明明,王慧娜,缪红,张万红,赵桂琴..熟地黄、山茱萸、茯苓单煎液与合煎液中毛蕊花糖苷、没食子酸煎出量的变化[J].中国药房,2017,28(31):4350-4354,5.基金项目
国家科技支撑计划项目(No.2011BAI07B04) （No.2011BAI07B04）
河北省教育厅项目(No.ZD2016061) （No.ZD2016061）
河北省中医药管理局项目(No. 2015034) （No. 2015034）
河北省高校重点学科建设项目(No.冀教高〔2013〕4号) （No.冀教高〔2013〕4号）
