中国药房2017，Vol.28Issue(31)：4429-4433,5.DOI:10.6039/j.issn.1001-0408.2017.31.28
Box-Behnken设计-响应面法优化桂枝茯苓胶囊的闪式提取工艺
Optimization of Flash Extraction Technology for Guizhi Fuling Capsule by Box-Behnken Design-response Surface Method
摘要
Abstract
OBJECTIVE:To optimize the flash extraction technology for Guizhi fuling capsule. METHODS:Using blade speed,liquid-solid ratio,extraction time as investigation factors,using the comprehensive evaluation values consisting of transfer rates of gallic acid,paeoniflorin,benzoic acid,cinnamic acid,benzoyl paeoniflorin,amygdalin as investigation index,single fac-tor test was combined with Box-Behnken design-response surface method to optimize the flash extraction technology for Guizhi ful-ing capsule. Verification test was conducted and compared with conventional decoction extraction method(extracting twice,totally 240 min). RESULTS:The optimal flash extraction technology for Guizhi fuling capsule was using water as extraction solvent with blade speed of 5600 r/min and liquid-solid ratio of 10.5:1,extracting for 60 s. The average comprehensive evaluation value of veri-fication test was 85.40%(n=3),with relative error of 0.15% to the predicted value(85.55%),higher than decoction extraction method(72.65%). CONCLUSIONS:Optimized flash extraction technology for Guizhi fuling capsule is efficient and rapid.关键词
桂枝茯苓胶囊/单因素试验/Box-Behnken设计/响应面法/闪式提取/工艺优化Key words
Guizhi fuling capsule/Single factor test/Box-Behnken design/Response surface method/Flash extraction/Tech-nology extraction分类
医药卫生引用本文复制引用
王正宽,刘圆,石晓朦,王振中,萧伟..Box-Behnken设计-响应面法优化桂枝茯苓胶囊的闪式提取工艺[J].中国药房,2017,28(31):4429-4433,5.基金项目
国家"重大新药创制"科技重大专项——现代中药创新集群与数字制药技术平台课题(No.2013ZX09402203) （No.2013ZX09402203）
