中国药理学通报2017，Vol.33Issue(11)：1481-1484,4.DOI:10.3969/j.issn.1001-1978.2017.11.001
Neuregulin-1/ErbBs信号通路在慢性心力衰竭中的研究进展
The research progress of neuregulin-1/ErbBs signaling in chronic heart failure
摘要
Abstract
Neuregulin-1 (NRG-1) and the ErbBs family of receptor tyrosine kinases are widely expressed in the cardiovascular system.NRG-1/ErbBs signaling plays an essential role in physiology and pathophysiology of the heart,including stabilization of cardiac myocyte structure and function,promotion of cardiac myocyte proliferation and survival,inhibition of cardiac myocyte apoptosis,reduction of myocardial interstitial fibrosis,regulation of energy utilization,and enhancement of angiogenesis and so on.Therefore,NRG-1/ErbBs signaling is involved in the development and treatment of chronic heart failure(CHF).In this review,we bring the growing literature on NRG-1/ErbBs signaling and its significance in cardiovascular development and heart failure.关键词
神经调节蛋白-1/酪氨酸激酶受体/心肌细胞凋亡/心肌纤维化/心室重构/慢性心力衰竭Key words
neuregulin-1/receptor tyrosine kinases/cardiac myocyte apoptosis/myocardial fibrosis/ventricular remodeling/chronic heart failure分类
医药卫生引用本文复制引用
赵齐飞,魏聪,李红蓉,任红..Neuregulin-1/ErbBs信号通路在慢性心力衰竭中的研究进展[J].中国药理学通报,2017,33(11):1481-1484,4.基金项目
国家重点基础研究发展计划(973计划)资助项目(No 2012CB518606) （973计划）
