中国药理学通报2017，Vol.33Issue(11)：1485-1489,5.DOI:10.3969/j.issn.1001-1978.2017.11.002
桥粒芯糖蛋白表达和功能异常相关疾病及药物干预作用研究进展
Progression of related diseases of desmoglein abnormal and pharmacological intervention
摘要
Abstract
Desmoglein,which is a kind of Ca2+ dependent desmosomal cadherins protein,is a major part of the desmosomes.The desmoglein that distributes in the epithelium,myocardium and other tissues plays a very important role in the cell junction.In recent years,the detection of the abnormal expression and function of the desmoglein was proved in many diseases,such as skin,mucous membrane and tumor related diseases.Drugs may have an important effect in the treatment of diseases by interfering with the expression and function of desmoglein.In this paper,the distribution of several subtypes of the family of desmosomes and their functions in the related diseases are reviewed,which may also provide some new clues for the new drug research on the target of desmogleins.关键词
桥粒芯糖蛋白/分布/皮肤疾病/黏膜疾病/肿瘤/药物干预Key words
desmoglein/distribution/skin tissue diseases/disease of mucosa/neoplasms/pharmacological intervention分类
医药卫生引用本文复制引用
张译丹,尹清晟,耿诗涵,许梦习,庄朋伟,张艳军..桥粒芯糖蛋白表达和功能异常相关疾病及药物干预作用研究进展[J].中国药理学通报,2017,33(11):1485-1489,5.基金项目
长江学者和创新团队发展计划资助项目(No IRT_14R41) （No IRT_14R41）
