中国药理学通报2017，Vol.33Issue(11)：1489-1492,4.DOI:10.3969/j.issn.1001-1978.2017.11.003
肿瘤血管生成抑制剂的治疗局限和策略
Therapeutic limitations and strategies of angiogenesis inhibitors
摘要
Abstract
Angiogenesis inhibitors can make tumor cells in a harsh environment by inhibiting tumor angiogenesis and effectively blocking the tumor progression.However,anti-angiogenic drugs have shown lots of limitations,such as short-term duration,numerous adverse reactions,benefiting only a minority of tumor types and so on.These limitations restrain the development of new drugs and limit the cancer therapies.Many studies have revealed that tumor cells can escape from anti-angiogenic treatments through a variety of ways and mechanisms.In this review,we focus on the reasons behind the failure in treatments,so as to propose solving strategies to improve the current anti-angiogenic drug efficacy and provide reference for new angiogenesis inhibitors and clinical medication.关键词
肿瘤/血管生成抑制剂/血管正常化/肿瘤干细胞/精准治疗/策略Key words
neoplasm/angiogenesis inhibitors/vascular normalization/cancer stem cell/precision therapy/strategies分类
医药卫生引用本文复制引用
王蔚,余苏云,吴佳伟,黄帅,吴媛媛,陈文星,王爱云,陆茵..肿瘤血管生成抑制剂的治疗局限和策略[J].中国药理学通报,2017,33(11):1489-1492,4.基金项目
国家自然科学基金资助项目(No 81403260,81573859,81673725,81673648,81703765) （No 81403260,81573859,81673725,81673648,81703765）
中国博士后科学基金资助项目(No 2014M551639) （No 2014M551639）
江苏省博士后基金资助项目(No 1401138C) （No 1401138C）
江苏高校优秀科技创新团队计划[苏教科(2013)10号文] （2013）
江苏高校品牌专业建设工程资助项目(No PPZY2015A070) （No PPZY2015A070）
江苏高校中药学优势学科建设工程资助项目(PAPD)[苏政办发(2014)37号文] （PAPD）
江苏省中药药效及安全性评价重点实验室国家自然科学基金预研基金项目(No.JKLPSE201610) （No.JKLPSE201610）
