中国药理学通报2017，Vol.33Issue(11)：1496-1499,4.DOI:10.3969/j.issn.1001-1978.2017.11.005
AMPK信号通路在糖尿病心肌病中的研究进展
Research progress of AMPK pathway in diabetic cardiomyopathy
摘要
Abstract
AMP-activated protein kinase (AMPK) is one of the most important sensor molecules which regulates biological energy homeostasis,activating the upstream kinase LKB1 and CaMKK beta and Tak1 and so on.AMP/ATP ratio can modulate AMPK activity,controlling the decomposition and synthesis pathway of energy metabolism,activating AMPK during skeletal muscle contraction and myocardial ischemia,adjusting metabolism of fat cells and blood vessel function,promoting glucose transport and fatty acid oxidation.With atherosclerosis,hypertension and other potential causes ruled out,diabetic cardiomyopathy (DCM) is an independent primary disease resulted from abnormal structure and function of myocardium induced by diabetes,and DCM even brings about death in patients.Due to its regulation of blood sugar levels,fatty acid oxidation and glycogen metabolism,AMPK may play a vital role in the process of DCM.Based on literature review,this paper summarizes the role of AMPK pathway in the process of DCM.关键词
AMPK/能量代谢/心肌缺血/葡萄糖/脂肪酸/糖尿病性心肌病Key words
AMPK/energy metabolism/myocardial ischemia/glucose/fatty acids/diabetic cardiomyopathy分类
医药卫生引用本文复制引用
张景怡,鲍翠玉,李晶..AMPK信号通路在糖尿病心肌病中的研究进展[J].中国药理学通报,2017,33(11):1496-1499,4.基金项目
国家自然科学基金资助项目(No 51703055) （No 51703055）
湖北省自然科学基金资助项目(No 2017CFB699,2015CFC773) （No 2017CFB699,2015CFC773）
湖北省教育厅科学研究计划项目(No B201696) （No B201696）
湖北科技学院糖尿病专项基金项目(No 2016-18XZ09,14ZX-02) （No 2016-18XZ09,14ZX-02）
