安徽医科大学学报2017，Vol.52Issue(9)：1346-1351,6.DOI:10.19405/j.cnki.issn1000-1492.2017.09.020
人胃癌组织BRSK2表达与患者临床病理学参数及预后的关系
Expression of BRSK2 in human gastric cancer and its relationship with clinicopathological parameters and prognosis
摘要
Abstract
Objective To evaluate the correlations of BRSK2 expression with clinicopathological parameters and prognosis in gastric cancer patients.Methods BRSK2 expression in 121 gastric cancer samples and 46 adjacent normal epithelial tissues from gastric cancer patients were detected by immunohistochemistry.Results BRSK2 decreased expression in 62 of 121 cases of gastric cancer (51.24％),which was significantly higher than adjacent noncancerous epithelial tissues (x2 =55.22,P ＜ 0.001).In addition,BRSK2 decreased expression was significantly correlated with depth of invasion/T classification (P ＜ 0.001),Histological differentiation (P =0.006),TNM stage (P ＜ 0.001),and lymph node metastasis (P =0.001).Kaplan-Meier survival analysis showed that the overall survival time and disease-free survival time in patients with BRSK2-negative expression were shorter.Multivariate analysis further demonstrated that BRSK2 was an independent prognostic factor for gastric cancer patients.Conclusion The decrease of BRSK2 expression in cancer tissues of patients with gastric cancer was associated with the progression and poor prognosis of the tumor,indicating that BRSK2 could be used as a molecular marker for the prognosis of gastric cancer patients and a potential therapeutic target.关键词
胃癌/BRSK2/免疫组织化学/预后Key words
gastric cancer/BRSK2/immunohistochemistry/prognosis分类
医药卫生引用本文复制引用
王小强,常家聪,叶啸天,高翔,曹先东,郭爱军..人胃癌组织BRSK2表达与患者临床病理学参数及预后的关系[J].安徽医科大学学报,2017,52(9):1346-1351,6.基金项目
安徽省科技攻关计划项目(编号:1501ld04040) （编号:1501ld04040）
