安徽医科大学学报2017，Vol.52Issue(9)：1370-1374,5.DOI:10.19405/j.cnki.issn1000-1492.2017.09.025
老年患者远端缺血再灌注损伤对术后认知功能障碍发生率的影响
Effect of the distal ischemic injury on the incidence of postoperative cognitive function in the elderly
摘要
Abstract
Objective To explore the effect of knee arthroplasty on the incidence of postoperative cognitive dysfunction(POCD) in elderly patients,and investigate the correlation between POCD incidence and serum neuron specific enolase (NSE),tumor necrosis factor(TNF)-α or S100β protein.Methods Forty elderly patients underwent knee arthroplasty were randomly divided into two groups by a tourniquet blocking time,including limited time group(from the beginning of osteotomy to the end of the prosthetic installation,G1 group) and entire group (the whole operation,G2 group).The vital signs of two groups were recorded during the operation.Blood samples were collected respectively at the 1 th day before surgery and 4th days after surgery,and then the protein levels of NSE,TNF-α,S100β were detected by ELISA kits.Neuropsychological tests were performed at the 1th day before surgery and 4th days after surgery.According to Murkin JM's Z value calculation formula,the incidence of POCD was calculated in two groups.Results The protein levels of NSE,TNF-α and S100β were significantly increased in G2 group compared with G1 group at the 4th days after surgery (P ＜ 0.05).The results of neuropsychological tests showed that the incidence of POCD was 10％ in G1 group,and 25％ in G2 group,and POCD incidence of G2 group was higher than that of G1group.The results of correlation analysis showed that POCD incidence of G2 group was correlated with the serum levels of NSE,TNF-α and S100β (P ＜ 0.05).Conclusion Our results demonstrate that long-term distal ischemic injury increase the incidence of POCD in elderly patients,and POCD incidence are related with serum levels of NSE,TNF-α and S100β.关键词
老年患者/缺血/再灌注损伤/术后认知功能障碍/神经心理学测评Key words
ederly patients/ischemic injury/postoperative cognitive dysfunction/neuropsychological test分类
医药卫生引用本文复制引用
王义桥,刘德宝,高培,李元海..老年患者远端缺血再灌注损伤对术后认知功能障碍发生率的影响[J].安徽医科大学学报,2017,52(9):1370-1374,5.基金项目
2013年高等学校博士学科点专项科研基金联合资助课题(编号:20133420110009) （编号:20133420110009）
