安徽医科大学学报2017，Vol.52Issue(10)：1563-1567,5.DOI:10.19405/j.cnki.issn1000-1492.2017.10.033
血清胃蛋白酶原、促胃液素-17和幽门螺杆菌抗体对胃癌前状态筛查能力的评价
Evaluation of serum pepsinogen, gastrin-17 and Helicobacter pylori antibody in screening gastric precancerous state
摘要
Abstract
Objective To investigate the correlation between serum pepsinogen,gastrin-17,anti-Helicobacter pylori antibodies and the histologic diagnosis of gastric precancerous state.Methods 331 adult individuals with chronic gastritis were enrolled in this study,and observed serum markers level in different histolgic diagnosis (including mucosal atrophy,intestinal metaplasia,intraepithelial neoplasia,OLGA staging and OLGIM staging) and the status of gastric precancerous state in ABC method.Results ① Serum gastrin-17 level was lower in those who suffered mucosal atrophy only in antrum than those who suffered no mucosal atrophy,serum PGR level was lower in those who suffered mucosal atrophy only in corpus than those who suffered no mucosal atrophy,serum PG Ⅰ and PGR level were lower in those who suffered mucosal atrophy in both antrum and corpus than those who suffered no mucosal atrophy;②Serum gastrin-17 level was lower in those who suffered intestinal metaplasia only in antrum than those who suffered no intestinal metaplasia,serum PG Ⅰ level was lower in those who suffered intestinal metaplasia in both antrum and corpus than those who suffered no intestinal metaplasia;③ Serum PG Ⅰ level was lower in those who suffered low-grade intraepithelial neoplasia in both antrum and corpus than those who suffered no low-grade intraepithelial neoplasia;④ Serum PG Ⅰ level descended gradually following OLGA staging become more serious,especially in staging Ⅳ;⑤ Serum PG Ⅰ level descended gradually following OLGIM staging become more serious,especially in staging Ⅳ;⑥ Although the proportion of gastric precancerous state in high-risk group (including group B,group C,and group D) was higher than that in low-risk group(group A) according to the ABC method,there was still a certain proportion patients in low-risk group suffered chronic atrophic gastritis and low-grade intraepithelial neoplasia(50.16％,15.96％ respectively).Conclusion Serum pepsinogen and gastrin-17 are useful to assess the risk of gastric precancerous state.The ABC method is effective in screening early gastric cancer to some extent.However,there is still a risk of pre-gastric cancer in the low-risk group.关键词
胃癌前状态/血清学指标/OLGA分期和OLGIM分期Key words
gastric precancerous state/serum markers/OLGA staging and OLGIM staging分类
医药卫生引用本文复制引用
刘德地,张磊,王亚雷,李楠,冯慧,许建明..血清胃蛋白酶原、促胃液素-17和幽门螺杆菌抗体对胃癌前状态筛查能力的评价[J].安徽医科大学学报,2017,52(10):1563-1567,5.基金项目
安徽省科技攻关计划项目(编号:15011d04043) （编号:15011d04043）
