吉林大学学报（医学版）2017，Vol.43Issue(6)：1182-1185,4.DOI:10.13481/j.1671-587x.20170621
血清胃蛋白酶原、胃泌素17和幽门螺杆菌抗体检测在胃癌筛查中的应用
Application of detection of serum pepsinogen,gastrin-17 and Helicobacter pylori antibody in gastric cancer screening
摘要
Abstract
Objective:To investigate the feasibility of detection of serum pepsinogen (PG),gastrin-17 (G-17) and Helicobacter pylori antibody (anti-HP)in the gastric cancer screening,and to elucidate its clinical value. Methods:A total of 208 patients with early gastric cancer were selected as observation group;at the same time, 208 healthy examinees were regarded as blank control group.The levels of PGⅠ,PGⅡ and G-17 of the subjects in two groups were detected by enzyme-linked immunosorbent assay and latex-enhanced immunoturbidimetry;the positive rates of anti-HP were detected by 13 C urea breath test;the serum levels of PG Ⅰ,PG Ⅱ and PG Ⅰ /PGⅡ ratio of the anti-HP positive subjects (anti-HP positive group)and anti-HP negative subjects (anti-HP negative group)were compared and analyzed.Results:Compared with blank control group,the serum PGⅠ / PGⅡ ratio and PGⅠ level of the subjects in observation group were significantly decreased (P <0.01),and the levels of PG Ⅱ,G-17 and the positive rate of anti-HP were increased (P <0.01).Compared with anti-HP negative group,the serum PGⅠ / PGⅡ ratio and PGⅠ level of the subjects in anti-HP positive group were significantly decreased (P <0.01).The levels of PGⅡ and G-17 were significantly increased (P < 0.01).Conclusion:The detection of positive rate of anti-HP combined with the ratio of PGⅠ /PGⅡ has important clinical significance in gastric cancer screening.The levels of G-17 and PG Ⅱ in the epithelial neoplasia lesion tissue can be used as indicators of gastric precancerous lesions.关键词
胃蛋白酶原/胃泌素17/幽门螺杆菌抗体/胃肿瘤Key words
pepsinogen/gastrin-17/Helicobacter pylori antibody/stomach neoplasms分类
医药卫生引用本文复制引用
刘刚,赵民学,王德盛..血清胃蛋白酶原、胃泌素17和幽门螺杆菌抗体检测在胃癌筛查中的应用[J].吉林大学学报（医学版）,2017,43(6):1182-1185,4.基金项目
国家自然科学基金资助课题(81672341) （81672341）
