吉林大学学报（医学版）2017，Vol.43Issue(6)：1243-1247,5.DOI:10.13481/j.1671-587x.20170632
经皮椎体成形术联合125I放射粒子植入术治疗椎体转移瘤的效果评价
Effectiveness evaluation on percutaneous vertebroplasty combined with 125 I radioactive particle implantation in treatment of vertebral metastasis
摘要
Abstract
Objective: To evaluate the clinical effect of pereutaneous vertbroplasty (PVP) combined with implantation of iodine-125 (125 I)radioactive particle in the treatment of vertebral metastasis,and to provide basis for the treatment of vertebral metastasis.Methods:A total of 69 patients with vertebral metastasis were divided into test group (n=32)and control group (n=37);the patients in test group were treated with PVP comined with implantation 125 I radioactive particle and the patients in control group were treated with PVP only.The heights of anterior and posterior vertebral bodies of the patients before and after treatment were detected by X-ray.The numerical rating scale (NRS)scores,pain relief rate and the incidence of surgical complications of the patients were recorded before operation and 1 d,1 week,1 month,3 months,and 6 months after operation.Results:The operation was successfully performed in all the patients without local bleeding;there were no movement dysfunction and nerve compression phenomenon.There was no leakage of bone cement.All the 125 I radioactive particles located well and there was no particle obscission.The heights of vertebral bodies of the patients in two groups after operation were increased compared with before operation (P <0.05).The NRS scores of the patients in two groups s at 1 d,1 week,1 month,3 months,6 months after operation were significantly decreased compared with before operation (P <0.05);compared with control group,the NRS scores of the patients in test group at 1 d,1 week, 1 month,3 months,6 months after operation were decreased (P <0.05).The incidence of pulmonary embolism or radiation myelitis complications was about 4.3% in 69 patients.Compared with control group,the difference in the incidence of complications of the patients in test group was not significant (P < 0.05 ).Conclusion:PVP combined with 125 I radioactive particle implantation is a safe and effective method in the treatment of vertebral metastasis,which can relieve the pain of the patients obviously compared with PVP.关键词
经皮椎体成形术/125I放射性粒子/椎体转移瘤/数字评分法Key words
pereutaneous vertbroplasty/iodine-125 (125I)radioactive particle/vertebral metastasis/numerical rating scale分类
医药卫生引用本文复制引用
王骏臣,胡玮,余新林,李月春,郭海国,冯智军..经皮椎体成形术联合125I放射粒子植入术治疗椎体转移瘤的效果评价[J].吉林大学学报（医学版）,2017,43(6):1243-1247,5.基金项目
西北民族大学中央高校基本科研业务费专项基金资助课题(1001680715) （1001680715）
