磁共振成像2017，Vol.8Issue(11)：801-806,6.DOI:10.12015/issn.1674-8034.2017.11.001
三维准连续动脉自旋标记技术中不同PLD值对单侧大脑中动脉狭窄或闭塞患者脑血流灌注的评估
Cerebral perfusion varieties using 3D pseudo-continuous arterial spin labeling with different PLD in patients with unilateral middle cerebral artery stenosis or occlusion
摘要
Abstract
Objective: To assess the differences of different postlabeling delay (PLD) state of cerebral blood perfusion and clinical value. Materials and Methods: Patients with unilateral middle cerebral artery stenosis or occlusion were collected (n=30), who underwent MRI, three-dimensional time of flight magnetic resonance angiography (3D-TOF-MRA), diffusion weighted imaging (DWI) and three-dimensional pulsed continuous arterial spin labeling (3D pCASL) (PLD=1.5 s, PLD=2.5 s) scanning. All patients were divided into DWI (+) and DWI (-) according to ADC value. Cerebral blood flow (CBF) values (CBF1.5, CBF2.5) and ADC values of lesions in DWI (+) and MCA territory in responsible side in DWI (-) were measured by two observers, the relative areas of low perfusion and high DWI signal region were further calculated and NIHSS scores were recorded (n=16). ICC was used to assess the consistency between the two measurers; the difference of low perfusion detection rate was analyzed by Chi-square test, the differences of CBF values between two groups were analyzed by independent sample t test, the differences of CBF values in a group and then the relative areas were analyzed by paired sample t test. Pearson and Spearman correlation analysis were used to analyze the correlation between CBF values vs. ADC values and NIHSS scores. Results: The good consistency was acquired between the two measurers (ICC=0.98, P<0.05). CBF1.5 values were lower than those of CBF2.5 in all patients or DWI (+) or DWI (-) (t=-7.207, P=0.000. t=-7.071, P=0.000. t=-3.641, P=0.004). Compared with DWI (-), CBF1.5 values and CBF2.5 values and ADC values of DWI (+) were decreased (t=-8.243, P=0.000. t=-5.536, P=0.000, t=-10.764, P=0.000). The detection rate of low perfusion was higher and the relative area value of low perfusion was larger with PLD=1.5 s than 2.5 s (χ2=7.239, P=0.007. 0.59±0.11, 0.21±0.09, t=4.20, P=0.006). The relative areas of high signal was 0.12±0.05 in DWI (+), which was lower than those of low perfusion with PLD= 1.5 s, but not differed to those with PLD=2.5 s (t=4.622, P=0.001. t=2.282, P=0.71). There was moderate positive correlation between CBF2.5 values and ADC values in DWI (+) group, moreover there was a moderate negative correlation between CBF1.5 values and NIHSS scores (r=0.50, P=0.035. r=-0.547, P=0.028). Conclusions: PLD of 1.5 s is sensitive to hypoperfusion and shows large ischemic area, which is in good consistency with clinical status. The combined application of PLD of 2.5 s and 1.5 s is better to assess collateral circulation.关键词
三维准连续性脉冲自旋标记技术/标记延迟时间/脑梗死/磁共振成像Key words
3D pseudo-continuous arterial spin labeling/Post labeling delay/Stroke/Magnetic resonance imaging分类
医药卫生引用本文复制引用
杜慧,王梦辰,陈敦超,尚劲,刘扬颖秋,王铭义,宋清伟,苗延巍..三维准连续动脉自旋标记技术中不同PLD值对单侧大脑中动脉狭窄或闭塞患者脑血流灌注的评估[J].磁共振成像,2017,8(11):801-806,6.基金项目
国家自然科学基金(编号:81671646)The research was supported by the National Natural Science Foundation of China (No. 81671646). （编号:81671646）
