南方医科大学学报2017，Vol.37Issue(9)：1201-1205,5.DOI:10.3969/j.issn.1673-4254.2017.09.10
长效干扰素治疗慢性乙型肝炎引发的精神心理异常及干预治疗效果分析
Depression and anxiety caused by pegylated interferon treatment in patients with chronic hepatitis B and the therapeutic effects of escitalopram and alprazolam
摘要
Abstract
Objective To evaluate the incidence of depression and anxiety caused by pegylated interferon α (PegIFN-α) treatment for chronic hepatitis B (CHB) and assess the efficacy of intervention with escitalopram and alprazolam.Methods A total of 165 CHB patients receiving PegIFN-α-based treatment for 12 weeks were assessed for moderate to severe depression and anxiety using Patient Health Questionnaire (PHQ-9) and 7-item Generalized Anxiety Disorder Scale (GAD-7)].The patients identified to have moderate to severe depression and anxiety treated with escitalopram or alprazolam and the psychological condition of the patients was assessed at the 2nd,4th and 8th weeks of the treatments.Results In the 165 patients receiving PegIFN-α treatment,51 patients developed moderate to severe psychiatric symptoms,incuding 37 (22.4％) with depression,31 (18.8％) with anxiety,and 17 (10.3％) with both.The symptoms of depression and anxiety was both significantly improved by intervention with escitalopram (P=0.000);alprazolam was effective for anxiety (P=0.001) but did not produce obvious effects on depression (P=0.904).Nevertheless,alprazolam had a much better therapeutic effect than escitalopram on anxiety in these patients (t=3.198,P=0.010).Conclusion Psychological symptoms are common in CHB patients receiving PegIFN-α treatment.The symptoms of depression and anxiety can be ameliorated by intervention with escitalopram and alprazolam,respectively.关键词
长效干扰素/慢性乙型肝炎/精神心理异常/干预治疗Key words
pegylated interferon/chronic hepatitis B/psychiatric symptoms/medical intervention引用本文复制引用
胡承光,周元平,袁国盛,黄华萍,刘俊维,周宇辰,任彦瑜,李园,谭文娟,苏梅蕾..长效干扰素治疗慢性乙型肝炎引发的精神心理异常及干预治疗效果分析[J].南方医科大学学报,2017,37(9):1201-1205,5.基金项目
国家自然科学基金(81470856) （81470856）
中国肝炎防治基金会课题(XJS20120601)Supported by National Natural Science Foundation of China (81470856). （XJS20120601）
