南方医科大学学报2017，Vol.37Issue(9)：1234-1241,8.DOI:10.3969/j.issn.1673-4254.2017.09.16
Wnt及整合素信号通路在大肠侧向发育型肿瘤中的表达及与其内镜形态学之间的关系
Expression of Wnt and integrin pathways in colorectal laterally spreading tumors and their correlation with endoscopic subtypes
吴杰 1霍继荣 1王东 1汪春莲 1吕梁1
作者信息
- 1. 中南大学湘雅二医院消化内科,湖南长沙410011
- 折叠
摘要
Abstract
Objective To investigate the expression of Wnt and integrin pathways in colorectal laterally spreading tumors (LSTs) and their correlation with the different endoscopic subtypes of LSTs to better understand the special growth mechanism of LSTs.Methods Fifty-two patients with colorectal LSTs were randomly selected from the cases diagnosed between January 1,2010 and June 10,2015 in our hospital,including 37 of nodular mixed type (LST-G-M),60 of homogeneous type (LST-G-H),5 of fiat elevated type (LST-NG-FE),and 4 of pseudodepressed type (LST-NG-PD).The expression of β-catenin,phosphoGSK-3β,paxillin and ILK in 52 colorectal LSTs and 15 protruded adenomas (PAs) were investigated by immunohistochemical staining.The correlation of β-catenin,phospho-GSK-3β,paxillin and ILK expressions among the endoscopic subtypes of LSTs were analyzed.Results β-catenin expression was significantly higher in LSTs than in Pas (P＜0.05).β-catenin,phospho-GSK-3β,paxillin and ILK expressions were significantly higher in LST-NG-PD than in Pas (P＜0.05).The expressions of β-catenin,phospho-GSK-3β and ILK expression were significantly correlated in LSTs (P＜0.05) but not in PAs (P＞0.05).Conclusion The macroscopic feature of LST-NG-PD may result from a special mechanism of development distinct from other endoscopic subtypes;ILK may play a role in regulating Wnt signaling in LSTs.关键词
大肠侧向发育型肿瘤/Wnt信号通路/整合素信号通路/β-catenin/内镜分型Key words
laterally spreading tumor/Wnt pathway/integrin pathway/β-catenin/endoscopic subtypes引用本文复制引用
吴杰,霍继荣,王东,汪春莲,吕梁..Wnt及整合素信号通路在大肠侧向发育型肿瘤中的表达及与其内镜形态学之间的关系[J].南方医科大学学报,2017,37(9):1234-1241,8.
