赖水青 1洪真真 2陈红梅 1林锦信 1邝建 1李延兵2
作者信息
- 1. 广东省人民医院//广东省医学科学院内分泌科,广东 广州 510080
- 2. 中山大学附属第一医院内分泌科,广东广州 510080
- 折叠
摘要
Abstract
Objective To investigate the correlation between liver and skeletal muscle fat contents and insulin resistance in obese individuals with different levels of glucose tolerance. Methods Ten non-obese individuals with normal glucose tolerance (NGT), 9 obese individuals with NGT, and 7 obese individuals with impaired glucose tolerance (IGT) were enrolled in this study. All the participants were examined for insulin sensitivity by hyperinsulinemic-euglycemic clamp and for liver and skeletal muscle fat accumulation quantified by proton magnetic resonance spectroscopy (1H MRS). The data were collected from the subjects including somatometric measurements, fasting plasma glucose, 2-h plasma glucose (2hPG), fasting insulin, and blood biochemistry. Linear correlation analysis and multiple linear stepwise regression analysis were used to analyze the relationship between ectopic fat accumulation and insulin resistance. Results The glucose infusion rates (GIR, presented as the M value) differed significantly among IGT-obese (3.95 ± 1.66 mg · kg-1 · min-1), NGT-obese (6.14 ± 1.90 mg · kg-1 · min-1) and NGT-non-obese (8.78 ± 2.46 mg · kg-1 · min-1) groups (P<0.05). The 3 groups also showed significant differences in liver fat contents [(15.23 ± 3.09)%, (6.25 ± 0.38)%, and (1.89 ± 0.90)%, respectively, P<0.05] and intramyocellular lipids in the tibialis anterior (2.69 ± 0.95, 2.61 ± 1.45, and 1.54 ± 0.66 mmol/kg, respectively, P<0.05). Linear analysis revealed that liver fat content, but not skeletal muscle fat content, was significantly correlated with the M value. Multiple linear stepwise regression analysis using M value as the dependent variable (Y) revealed that liver fat content (X) was an independent factor inversely correlated with the M value(regression equation: Y=-30.562X+9.007, R2=0.717, P<0.01). Conclusions Liver fat accumulation, but not skeletal muscle fat accumulation, is correlated with insulin resistance and impaired glucose metabolism.关键词
异位脂肪沉积/胰岛素抵抗/高胰岛素-正常葡萄糖钳夹试验/磁共振质子谱Key words
ectopic fat accumulation/insulin resistance/hyperinsulinemic-euglycemic clamp/proton magnetic resonance spectroscopy
