南方医科大学学报2017，Vol.37Issue(11)：1551-1554,4.DOI:10.3969/j.issn.1673-4254.2017.11.21
机械法准分子激光上皮瓣下角膜磨镶术后早期泪液中肝细胞生长因子含量与角膜上皮下雾状混浊的相关性
Association between hepatocyte growth factor in tears and corneal haze in rabbits early after epipolis laser in situ keratomileusis
摘要
Abstract
Objective To study the dynamic changes of levels of hepatocyte growth factor (HGF) in tears and their association with corneal haze in rabbits early after epipolis laser in situ keratomileusis (Epi-LASIK). Methods Twenty-four New Zealand rabbits received Epi-LASIK with an ablation depth of 100 μm in one eye and of 150 μm in the other eye. Before and at 3, 7, 14, and 30 days after the surgery, the level of HGF in tears collected from the rabbits was measured using enzyme-linked immunosorbent assay (ELISA), and corneal haze was graded after surgery. Results In all the rabbits, corneal epithelium healing occurred in 3 to 5 days after Epi-LASIK. Corneal haze appeared 3 days postoperatively in the rabbits accompanied by increased levels of HGF in tears. At 3, 7, 14, and 30 days after the surgery, the rabbits with an ablation depth of 150 μm showed more obvious corneal haze (P<0.05) and significantly higher levels of HGF in tears than those with an ablation depth of 100 μm (P<0.05). Conclusion In rabbits receiving Epi-LASIK, HGF levels in tears and the grade of corneal haze show a positive correlation early after the surgery and are both related with the depth of ablation.关键词
Epi-LASIK/泪液/肝细胞生长因子/雾状混浊Key words
epipolis laser in situ keratomileusis/tear/hepatocyte growth factor/haze引用本文复制引用
陈静,韩苏宁,邹秀兰,邹玉平..机械法准分子激光上皮瓣下角膜磨镶术后早期泪液中肝细胞生长因子含量与角膜上皮下雾状混浊的相关性[J].南方医科大学学报,2017,37(11):1551-1554,4.基金项目
广东省医学科研基金(B2010249) （B2010249）
