福建师范大学学报（自然科学版）2017，Vol.33Issue(6)：90-94,116,6.DOI:10.12046/j.issn.1000-5277.2017.06.013
游泳训练对糖尿病前期大鼠血管损伤和氧化应激的影响
Effects of Swimming Training on Vascular Injury and Oxidative Stress in Prediabetic Rats
摘要
Abstract
To investigate the effects of swimming exercise on vascular injury and oxidative stress state in prediabetic rat.Male Sprague Dawley rats were induced to the prediabetic model by high-energy emulsion,then they were randomly divided into four groups (sedentary control group,swimming control group,sedentary prediabetic group,swimming prediabetic group).Rats were sacrificed after 8 weeks' swimming training program.Malondialdehyde (MDA),superoxide-dismutase (SOD),peroxidase (POD),total antioxidant capacity (T-AOC),nitric oxide (NO) were detected in the serum and thoracic aorta.Vascular pathological changes were examined by HE staining.Compared with control group,in the serum and aorta of prediabetic rat,we found the visible vascular injury,significant oxidative stress state and remarkably decline of NO content.After eight weeks of swimming training,prediabetic rat showed obviously increase of the antioxidant capacity and NO content in serum and aorta and distinctly improving vascular damage.In conclusion,swimming training can balance oxidative stress state in prediabetic rat,so as to play a role of protection of blood vessels.关键词
游泳训练/糖尿病前期/大鼠/血管损伤/氧化应激Key words
swimming training/prediabete/rat/vascular injury/oxidative stress分类
社会科学引用本文复制引用
王少兵,刘一平,林清强,王正朝..游泳训练对糖尿病前期大鼠血管损伤和氧化应激的影响[J].福建师范大学学报（自然科学版）,2017,33(6):90-94,116,6.基金项目
福建省自然科学基金资助项目(2016J01150、2017J01627) （2016J01150、2017J01627）
