口腔疾病防治2017，Vol.25Issue(11)：712-717,6.DOI:10.12016/j.issn.2096-1456.2017.11.007
血管生成相关因子在口腔扁平苔藓中的表达
Angiogenesis-related factors expression in oral lichen planus
摘要
Abstract
Objective To detect the expression of vascular endothelial growth factor (VEGF), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) in oral lichen planus (OLP). Methods Thirty OLP patients and fifteen healthy subjects were enrolled in the study. Serum were collected from 15 healthy volunteers as con-trols. Normal tissues were collected from surgical department as immunohistochemical analysis. The levels of VEGF, ICAM-1, VCAM-1 in serum were measured by ELISA. Immunohistochemical analysis of VEGF, ICAM-1, VCAM-1 were carried out by the means of primary antibodies and anti-VEGF, anti-CD106 antigen (VCAM-1) and anti-CD54 anti-gen (ICAM-1). Results ELISA results showed no expression differences for VEGF between the two groups. Whereas, the levels of ICAM-1, VCAM-1 in OLP group were significantly higher than those in control group (P<0.05). Immuno-histochemical results reveal the presence of a significant angiogenesis in OLP patients through the immunoexpression of VEGF, ICAM-1, VCAM-1 according to the percentage of stained cells (P<0.05). Conclusion Regarding the results, it seems that high expression of VCAM-1 and ICAM-1 are related to oral lichen planus.关键词
口腔扁平苔藓/血管生成/酶联免疫吸附测定/VEGF/ICAM-1/VCAM-1Key words
Oral lichen planus/Angiogenesis/ELISA/VEGF/ICAM-1/VCAM-1分类
医药卫生引用本文复制引用
孟文霞,郭薇,李志强,谢宝仪,殷操,姚艳梅,李菊兄..血管生成相关因子在口腔扁平苔藓中的表达[J].口腔疾病防治,2017,25(11):712-717,6.基金项目
国家自然科学基金(81500850) （81500850）
广东省医学科学技术研究基金(A2015537) （A2015537）
