口腔疾病防治2017，Vol.25Issue(11)：718-722,5.DOI:10.12016/j.issn.2096-1456.2017.11.008
IL-6-572基因多态性与侵袭性牙周炎易感性的相关性研究
Relationship between interleukin-6 -572 gene polymorphism and aggressive periodontitis in Chinese
摘要
Abstract
Objective To investigate the association between interleukin-6-572 gene polymorphism and aggressive periodontitis. Methods A case-control study involved 83 patients with aggressive periodontitis (AgP) and 69 health con-trols was held, and the genotype and allele distributions of interleukin-6-572 gene polymorphism were analyzed by PCR-RFLP. Results There was statistically significant differences in the genotype distribution by the chi-square test in the two groups (x2=13.710, P=0.001). The distribution of allele frequencies in AgP group was statistically different (x2=13.213, P<0.001) from the healthy control group, and the OR for the G allele is 2.988 (95%CI:1.634-5.465) when com-pared with the C allele. Conclusion IL-6 -572 gene polymorphism is associated with the susceptibility to AgP in Chi-nese Han population of Guangdong, and the IL-6-572 G allele might be a risk factor of the genetic susceptibility to AgP.关键词
白细胞介素-6/慢性牙周炎/侵袭性牙周炎/单核苷酸多态性/等位基因Key words
Interleukin-6/Chronic periodontitis/Aggressive periodontitis/Single nucleotide polymorphism/Allele分类
医药卫生引用本文复制引用
李璟,梁菁,徐婷,谭凤清,刘娟,曾雄群..IL-6-572基因多态性与侵袭性牙周炎易感性的相关性研究[J].口腔疾病防治,2017,25(11):718-722,5.基金项目
广州市海珠区科技计划项目(2017-43) （2017-43）
广东省自然科学基金(06022942) （06022942）
