摘要
Abstract
Objective To investigate the effects of lateral lumbar intervertebral fomixectomy (PTED) on intraoperative bleeding volume and postoperative serum levels of prostaglandin E2 (PGE2) and soluble tumor necrosis factor type Ⅰ (sTNF-RI) receptor in patients with lumbar disc herniation.Methods From October,2013 to August,2016,86 cases of lumbar disc herniation treated at our hospital were divided into a control group and an observation group according to different surgery plans,43 cases for each group.The control group were treated with posterior laminectomy (FD) and the observation group with PTED.The patients were followed up for 6 months.The surgical-related indicators and surgical results were analyzed.The pain degree (VAS),dysfunction (ODI),serum levels of PGE2 and sTNF-RI,and quality of life of the two groups were compared before and after the treatment.Results Compared with the control group,the observation group had smaller incision,lower intraoperative bleeding volume,better postoperative bed rest,and shorter hospital stay (all P ＜ 0.05).There were no statistical differences in VAS,ODI,and quality of life scores between the two groups (all P ＞0.05).The VAS and ODI scores of the observation group were lower than those of the control group,with statistical differences (all P ＜0.05).There was no statistical difference in the excellent rate between the observation group (93.02％,40/43) and the control group (88.37％,38/43) (P ＞ 0.05).There were no statistical differences in the serum levels of PGE2 and sTNF-RI between the two groups before the treatment (both P ＞ 0.05).Compared with the control group,the level of serum PGE2 in the observation group was lower and the serum level of sTNF-RI was higher,with statistical differences (both P ＜0.05).Conclusions PTED in the treatment of lumbar disc herniation can reduce the intraoperative bleeding volume,decrease the postoperative serum PGE2 level,increase the serum sTNF-RI level,significantly alleviate the patients' postoperative pain,improve the dysfunction degree,and promote the patients' postoperative recovery and has more significant effect.关键词
侧路椎间孔镜髓核摘除术/腰椎间盘突出症/术中出血量/PGE2/sTNF-RIKey words
Lateral lumbar intervertebral fornixectomy/Lumbar disc herniation/Intraoperative bleeding volume/PGE2/sTNF-RI
