摘要
Abstract
Objective To investigate the effect of magnesium sulfate combined with nifedipine on 24 h urinary protein quantification,erythrocyte aggregation index,and pregnancy outcomes in patients with pregnancy induced hypertension syndrome (PIH).Methods From August 2014 to July 2016,75 patients with PIH in our hospital were selected and divided into single group (n=37) and combined group (n=38) according to the treatment regimen.The single group was treated with magnesium sulfate,and the combined group was treated with magnesium sulfate + nifedipine.After delivery,therapeutic effect and pregnancy outcomes were statistically analyzed between the two groups,and blood pressure (systolic blood pressure,diastolic blood pressure) and laboratory indicators (24 h urinary protein quantification,plasma viscosity,erythrocyte aggregation index,and hematocrit) levels were compared between the two groups before and after treatment.Results The total effective rate in the combined group [92.11％ (35/38)] was significantly higher than that in the single group [70.27％ (26/37)] (P＜0.05).There were no statistically significant differences in systolic and diastolic blood pressure between the two groups before treatment (P＞0.05);after treatment,the systolic and diastolic blood pressure levels in the combined group were lower than those in the single group,with statistically significant differences (P＜0.05).There were no statistically significant differences in the laboratory indexes levels between the two groups before treatment (P＞0.05);after treatment,the 24 h urinary protein quantification,plasma viscosity,erythrocyte aggregation index,and hematocrit in the combined group were lower than those in the single group,with statistically significant differences (P＜0.05).There were no statistically significant differences in the rates of placental abruption and neonatal asphyxia between the two groups (P＞0.05);the rates of premature delivery,fetal distress,postpartum hemorrhage,and cesarean section in the combined group were lower than those in the single group,with statistically significant differences (P＜0.05).Conclusion Magnesium sulfate combined with nifedipine in the treatment of PIH can effectively control blood pressure,reduce 24h urine protein quantification and erythrocyte aggregation index,improve the pregnancy outcomes,with more significant effect.关键词
硫酸镁/硝苯地平/妊娠高血压综合征/24h尿蛋白定量/红细胞聚集指数/妊娠结局Key words
Magnesium sulfate/Nifedipine/Pregnancy-induced hypertension syndrome/24 h urinary protein quantification/Erythrocyte aggregation index/Pregnancy outcome
