国际生殖健康/计划生育杂志2017，Vol.36Issue(6)：477-481,5.
磷脂酶C-zeta与男性不育
Phospholipase C-zeta and Male Infertility
摘要
Abstract
Oocytes activation is the first step of embryonic development, which is triggered by a series of cytoplasmic calcium (Ca2 +) oscillations in mammals. Sperm-egg fusion initiates these Ca2 + oscillations by introducing a sperm-specific protein factor into oocytes cytoplasm. This protein factor has been indiated to be sperm-specific phospholipase C (PLC), termed PLC-zeta (PLCζ). Moreover, increasing clinical evidence revealed that some types of male infertility could be related with the aberrant expression of PLCζ and its localization, structure and function in human sperm. PLCζ can be used as a potential diagnostic and prognostic indicator of male infertility. Microinjection of recombinant human PLCζ protein could thus provide an efficient biological solution for inducing artificial activation of oocytes. This review is about the PLCζand oocytes activation, the PLCζexpression and localization pattern, and male infertility, and advance of PLCζ in the clinical applications of male infertility.关键词
卵母细胞/Ca2+振荡/钙/信号传导/不育,男(雄)性/磷脂酶C-zetaKey words
Oocytes/Ca2+oscillations/Calcium/Signal transduction/Infertility,male/Phospholipase C zeta引用本文复制引用
陈鑫,刁红录,张昌军,邓锴..磷脂酶C-zeta与男性不育[J].国际生殖健康/计划生育杂志,2017,36(6):477-481,5.基金项目
国家自然科学基金(81401200) （81401200）
湖北省教育厅科学技术研究项目(B2015493) （B2015493）
