河北医学2017，Vol.23Issue(11)：1761-1764,4.DOI:10.3969/j.issn.1006-6233.2017.11.001
TACE联合HIFU治疗老年原发性肝癌疗效及对患者免疫功能的影响
Effect of TACE Combined with HIFU on Elderly Patients with Primary Liver Cancer and its Effect on Immune Function
摘要
Abstract
Objective:To investigate the clinical efficacy of TACE ( hepatic arterial chemoembolization) combined with HIFU ( high intensity focused ultrasound) in elderly patients with primary liver cancer and its effect on immune function. Methods:84 patients with primary hepatocellular carcinoma were randomly divided into control group and observation group ( n = 42) . The patients were randomly divided into control group and observation group. The patients in the control group were treated with TACE alone. The patients in the observa-tion group were treated with TACE combined with HIFU. The changes of tumor volume and immune function were compared between the two groups. The median survival time and the survival rate after 3 years were com-pared. Results:After treatment with different methods, the tumor volume reduction and clinical treatment effi-ciency in the observation group were significantly better than those in the control group ( P <0.05) . The medi-an survival time and the survival rate of 1, 2 and 3 years after treatment in the observation group were signifi-cantly higher than those in the control group ( P <0.05) . The levels of immune globulin IgA, IgM, IgG of pa-tients in the observation group after treatment of 3 months were [(3.65 + 0.20) g/L], [(2.29 + 0.18) g/L], [(10.68 +0.84) g/L], were significantly higher than those in the control group [(3.23+0.24) g/L], [(1.81 +0.15 g/L]), [(8.76+0.67) g /L];the difference between the two groups was statistically signifi-cant ( t=8.71, 13.28, 11.58;P < 0.05);At three months after the treatment, the observation group patientscomplement C3 and C4 levels were [(1.49 + 0.06) g/L], [(0.34 + 0.03) g/L], the control group [(1.31+ 0.08) g/L], [(0.22 + 0.05) g/L], significant difference between the two groups (t=11.67, 13.34;P <0.05) . Conclusion:TACE combined with HIFU in elderly patients with primary liver cancer can effectively reduce the volume of the lesion, improve the immune kinetic energy of patients, improve the survival rate of patients, prolong the survival time, the effect is remarkable, worthy of clinical promotion.关键词
老年原发性肝癌/肝动脉灌注化疗栓塞/高强度聚焦超声/免疫功能Key words
Elderly primary hepatocellular carcinoma/Hepatic arterial chemoembolization/High intensity focused ultrasound/Immune function引用本文复制引用
谢焕琴,钟武装..TACE联合HIFU治疗老年原发性肝癌疗效及对患者免疫功能的影响[J].河北医学,2017,23(11):1761-1764,4.基金项目
广东省自然科学基金项目,(编号:2016A030310287) （编号:2016A030310287）
