河北医学2017，Vol.23Issue(11)：1791-1795,5.DOI:10.3969/j.issn.1006-6233.2017.11.009
佛香饮方对寒凝血瘀型痛经模型大鼠痛反应及血液流变学的影响
Foxiangyin on the Model Rats with Cold Coagulation and Blood Stasis Dysmenorrhea Pain Reaction and Blood Rheology
摘要
Abstract
Objective:To investigate the effects of water extract from Foxiang Yin ( FXY) on pain reac-tion and hemorheological parameters of rats with dysmenorrhe induced by cold coagulation and blood stasis to provide the experimental basis for clinical application of the prescription. Methods: The rats dysmenorrhea model induced by cold congealing and blood stasis were made by ice water bath and subcutaneous injection of adrenaline hydrochloride( Adr) combined with intraperitoneal injection of oxytocin. The inhibition rate of pain reaction was were calculated. The prothrombin time (PT), thrombin time (TT), activated partial thrombo-plastin time ( APTT) , the rate of platelet aggregation, hematocrit ( HCT) , K value of erythrocyte sedimenta-tion equation, plasma viscosity and whole blood viscosity were detected. Results:The CT,PT,TT and APTT in 1.8g/kg,3. 6g/kg and 7. 2g/kg doses groups of FXY are significantly longer than that in the model control group(P<0.05 or P<0.01). The platelet aggregation rate in high and middle 3.6g/kg and 7.2g/kg dose of FXY group were significantly lower than that of model group (P<0.05 or P<0.01). The hematocrit ( HCT) and ESR equation K values in all doses of FXY groups were significantly lower than that of model group ( P<0.05) . The plasma viscosity and whole blood viscosity in all dosage of FXY groups were lower than that of model group (P<0.05 or< P 0.01). Conclusion: FXY has obvious analgesic effect on the cold coagulation and blood stasis dysmenorrhea rats and improve high agglutination condition of blood and hemorheology is one of its action mechanisms.关键词
佛香饮/痛经/痛反应/寒凝血瘀/血液流变学Key words
Foxiang yin/Dysmenorrhea/Pain reaction/Cold coagulation and blood stasis/Hemorheological parameters引用本文复制引用
缪希红,冯晓静,杨新蕊,白云鹤..佛香饮方对寒凝血瘀型痛经模型大鼠痛反应及血液流变学的影响[J].河北医学,2017,23(11):1791-1795,5.基金项目
河北省中医药管理局资助项目,(编号:2016159) （编号:2016159）
