河北医学2017，Vol.23Issue(11)：1888-1892,5.DOI:10.3969/j.issn.1006-6233.2017.11.038
糖维胶囊对2型糖尿病患者脂质代谢血管内皮功能及微循环状态的影响
Effect of Tangwei Capsule on Lipid Metabolism, Vascular Endothelial Function and Microcirculation in Patients with Type 2 Diabetes Mellitus
摘要
Abstract
Objective:To investigate the effect of Tangwei capsule on lipid metabolism, vascular endo-thelial function and microcirculation in patients with type 2 diabetes mellitus ( T2DM) . Methods: A total of 200 patients with T2DM were randomly divided into the control group (100 cases) and the observation group (100 cases). The control group were treated with oral hypoglycemic agents or insulin, and the observation group were additionally treated with Tangwei capsule. Both groups were treated for 12 weeks. The levels of glu-cose and lipid metabolism, vascular endothelial function and microcirculation were compared between the two groups before and after treatment. Results:After the treatment, the insulin resistance ( IR) , total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) levels in the observation group were lower than those in the control group, while the high-density lipoprotein cholesterol ( HDL-C) level was higher than that in the control group ( P <0.05) . There were no significant differences in fasting blood glucose (FBG), postprandial 2h plasma glucose (2hPG) and glycosylated hemoglobin (HbA1c) between the two groups after treatment ( P >0.05) . After treatment, the nitric oxide ( NO) and endothelium dependent vasodi-lation (FMD) were higher, and plasma endothelin -1 (ET-1) was lower in the obsercation group than the control group ( P < 0.05) . After treatment, the diameters of afferent loop, efferent loop and top of loop were larger in the observation group than the control group, and the number of tube loop malformation was smaller than that in the control group ( P < 0.05) . Conclusion:Compared with routine hypoglycemic therapy, Tang-wei capsule combined with routine hypoglycemic therapy has more advantages in regulating abnormal lipid me-tabolism and vascular endothelial function and relieving microcirculation disturbance in patients with T2DM.关键词
2型糖尿病/糖维胶囊/脂质代谢/内皮素-1/微循环Key words
Type 2 diabetes mellitus/Tangwei capsule/Lipid metabolism/Endothelin-1/Microcirculation引用本文复制引用
白建乐,宫蕊..糖维胶囊对2型糖尿病患者脂质代谢血管内皮功能及微循环状态的影响[J].河北医学,2017,23(11):1888-1892,5.基金项目
河北省自然科学项目,(编号:C2009001352) （编号:C2009001352）
