吉林中医药2017，Vol.37Issue(11)：1099-1103,5.DOI:10.13463/j.cnki.jlzyy.2017.11.007
尿激酶溶栓联合自拟养心通痹汤治疗急性心肌梗死后缺血再灌注损伤
Treatment of thrombolysis combined with Heart-nourishing and Impediment-Diffusing decoction on reperfusion injury in patients with acute myocardial infarction
摘要
Abstract
Objective To investigate the effect of thrombolysis treatment combined with Heart-nourishing and Impediment-Diffusing decoction on reperfusion injury in patients with acute myocardial infarction. Methods 80 cases of acute myocardial infarction were randomly divided into observation group (40 cases) and control group (40 cases). The control group was treated with conventional thrombolytic therapy, and the observation group was treated with conventional thrombolytic therapy plus Heart-nourishing and Impediment-Diffusing decoction. The high-sensitivity c reactive protein (hs-CRP), creatine kinase (CK), creatine kinase isoenzyme (CK-MB) and high-sensitivity cardiac troponin T (hs-cTnT) were compared between the two groups. To observe the occurrence of the myocardial infarct size (MIS), left ventricular ejection fraction (LVEF) and major adverse cardiac events (MACE). Results Compared with before treatment, the two groups of hs-CRP, CK, CK-MB and hs-cTnT levels were gradually increased after treatment, but they began to decline after 24 h. After treatment, compared with the control group, the serum levels of hs-CRP, CK, CK-MB and hs-cTnT were lower in the observation group, and the difference was statistically significant (P<0.05). Compared with the control group during the same period, the MIS after the treatment of 1d (P<0.001) and 7 d after treatment (P<0.001) were lower in observation group, while the levels of LVEF were higher, the differences were statistically significant. Compared with the control group, the incidence rate of both MACE (P=0.014)and reperfusion arrhythmias (P=0.019)in observation group were low, the difference was statistically significant. Conclusion Thrombolysis treatment combined with Heart-nourishing and Impediment-Diffusing decoction on reperfusion injury in patients with acute myocardial infarction which can effectively reduce reperfusion injury, the incidence rate of MACE and improve left ventricular ejection function.关键词
急性心肌梗死/养心通痹汤/尿激酶/溶栓/再灌注损伤Key words
acute myocardial infarction/Heart-nourishing and impediment-diffusing decoction/prourokinase/thrombolysis/reperfusion injury分类
医药卫生引用本文复制引用
崔璐璐,聂俊军..尿激酶溶栓联合自拟养心通痹汤治疗急性心肌梗死后缺血再灌注损伤[J].吉林中医药,2017,37(11):1099-1103,5.基金项目
湖北省教育厅重点项目(D20141611). （D20141611）
