扬州大学学报（农业与生命科学版）2017，Vol.38Issue(3)：11-16,6.DOI:10.16872/j.cnki.1671-4652.2017.03.003
用光遗传方法激活前额叶皮层对脑区c-Fos表达的影响
Effects of optogenetics stimulation of prefrontal pyramidal neurons on c-Fos expression in prefrontal-related regions
摘要
Abstract
The method of optogenetics were used to stimulate PFC and the protein expression of immediate early gene c-fos (c-Fos) in cortical and subcortical regions was examined.Our data demonstrated that optogenetics stimulation of the PFC enhanced c-Fos expression in the PFC,as well as in orbitofrontal cortex,anterior cingulate cortex,motor cortex,and sensory cortex.The significant increases in c-Fos expression were observed in dorsomedial hypothalamus and paraventricular thalamus.No c-Fos positive cell was found in striatum,hippocampus,amygdala,and cerebellum.These results suggest that optogenetics stimulation of the PFC enhances neural activity of PFC-related cortical and subcortical regions,which may shed light on the circuit mechanism of how the prefrontal cortex regulates the cognitive function.关键词
光遗传学/锥体神经元/前额叶皮层/c-Fos/大鼠Key words
optogenetics/pyramidal neurons/prefrontal cortex/c-Fos/rats分类
生物科学引用本文复制引用
刘兆瑞,张雪寒..用光遗传方法激活前额叶皮层对脑区c-Fos表达的影响[J].扬州大学学报（农业与生命科学版）,2017,38(3):11-16,6.基金项目
国家自然科学基金资助项目(31571098) （31571098）
