解放军医学院学报2017，Vol.38Issue(9)：807-809,814,4.DOI:10.3969/j.issn.2095-5227.2017.09.001
血清氧化三甲胺水平与高龄老年慢性心力衰竭患者心功能相关性分析
Correlation between serum trimethylamine N-oxide level and cardiac function in old-old patients with chronic heart failure
摘要
Abstract
Objective To investigate the correlation between microbiota-dependent metabolite trimethylamine N-oxide (TMAO) and cardiac function in old-old patients with chronic heart failure.Methods One hundred and four old-old patients (age ≥ 80 years)with chronic heart failure were enrolled in the department of geriatrics,Nanjing General Hospital of Nanjing Military Area Command of Chinese PLA from January 2013 to February 2017,and they were divided into two groups:TMAO ＜ 5 μ mol/L group and TMAO ≥ 5 μ mol/L group.The basic clinical data,blood lipid levels,N-terminal pro-B-type natriuretic peptide (NT-proBNP) and left ventricular ejection fraction (LVEF) were analyzed and compared between two groups.Results Compared with TMAO ＜5 μ mol/L group,the level of NT-proBNP in TMAO ≥ 5 μ mol/L group increased significantly [(5 603.00 ± 770.40) ng/L vs (2 472.00 ± 383.70) ng/L,P=0.019],while LVEF decreased significantly (35.00％ ± 6.50％ vs 42.00％ ± 3.20％,P=0.024).Plasma TMAO level was positively correlated with NT-proBNP (r=0.73,P ＜ 0.01),and it was negatively correlated with LVEF (r=-0.58,P ＜ 0.01).Conclusion Plasma TMAO level is associated with cardiac function in old-old patients with chronic heart failure,which may be an important marker of cardiac function in old-old patients with heart failure.关键词
氧化三甲胺/慢性心力衰竭/老年人Key words
trimethylamine N-oxide/chronic heart failure/aged分类
医药卫生引用本文复制引用
张瑗,杨翔,吴宁,张兴虎,贡歌,钱晓明,万文辉..血清氧化三甲胺水平与高龄老年慢性心力衰竭患者心功能相关性分析[J].解放军医学院学报,2017,38(9):807-809,814,4.基金项目
部委级资助项目 （）
全军保健专项科研课题(13BJZ11) （13BJZ11）
南京军区南京总医院院管课题(2014064)Supported by Special Healthcare Scientific Research Project of PLA (13BJZ11) （2014064）
